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Recombinant Human NKG2D protein is a Human Full Length protein, in the 73 to 216 aa range, expressed in HEK 293, with >=95% purity and <= 0.005 EU/µg endotoxin level.
Alternative names=NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor, NKG2D, D12S2489E, KLRK1
- Purity
>=95% SDS-PAGE
- Endotoxin level
<= 0.005 EU/µg
- Expression system
HEK 293 cells
- Tags
Tag free
- Biologically active
No
- Sequence
I W S A V F L N S L F N Q E V Q I P L T E S Y C G P C P K N W I C Y K N N C Y Q F F D E S K N W Y E S Q A S C M S Q N A S L L K V Y S K E D Q D L L K L V K S Y H W M G L V H I P T N G S W Q W E D G S I L S P N L L T I I E M Q K G D C A L Y A S S F K G Y I E N C S T P N T Y I C M Q R T V
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Recombinant Human NKG2D protein is a Human Full Length protein, in the 73 to 216 aa range, expressed in HEK 293, with >=95% purity and <= 0.005 EU/µg endotoxin level.
Alternative names=NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor, NKG2D, D12S2489E, KLRK1
Key facts
- Purity
>=95% SDS-PAGE
- Endotoxin level
<= 0.005 EU/µg
- Expression system
HEK 293 cells
- Tags
Tag free
- Biologically active
No
- Predicted molecular weight
25 kDa
- Amino acids
73 to 216
- Sequence
I W S A V F L N S L F N Q E V Q I P L T E S Y C G P C P K N W I C Y K N N C Y Q F F D E S K N W Y E S Q A S C M S Q N A S L L K V Y S K E D Q D L L K L V K S Y H W M G L V H I P T N G S W Q W E D G S I L S P N L L T I I E M Q K G D C A L Y A S S F K G Y I E N C S T P N T Y I C M Q R T V
- Accession
- P26718-1
- Protein length
Full Length
- Animal free
No
- Nature
Recombinant
- Species
Human
- Reconstitution
Reconstitute with phosphate buffered saline.Store lyophilized form at room temperature. Reconstitute, aliquot and store at -80°C for 12 months or +4°C for 1 week.Avoid repeated freeze-thaw. Lyophilized contents may appear as either a translucent film or a white powder. This variance does not affect the quality of the product.
- Concentration
- Storage buffer
pH: 7.4
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic
Specifications
- Form
Lyophilized
General info
- Function
Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
Ambient
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