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AB172189

Recombinant Human NKIAMRE protein

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Recombinant Human NKIAMRE protein is a Human Full Length protein, in the 1 to 592 aa range, expressed in Baculovirus infected Sf9 cells, with >70%, suitable for SDS-PAGE, WB.

View Alternative Names

NKIAMRE, CDKL3, Cyclin-dependent kinase-like 3, Serine/threonine-protein kinase NKIAMRE

1 Images
SDS-PAGE - Recombinant Human NKIAMRE protein (AB172189)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human NKIAMRE protein (AB172189)

SDS-PAGE analysis of ab172189.

Key facts

Purity

>70% Densitometry

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE

applications

Biologically active

No

Accession

Q8IVW4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELKAKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRVIKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKENPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPNSRQEDPGPIQSQMEKGIFNERTGHSDQMANENKRKLNFSRSDRKEFHFPELPVTIQSKDTKGMEVKQIKMLKRESKKTESSKIPTLLNVDQNQEKQEGGDGHCEGKNLKRNRFFFW","proteinLength":"Full Length","predictedMolecularWeight":"68 kDa","actualMolecularWeight":null,"aminoAcidEnd":592,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q8IVW4","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NKIAMRE also known as Cyclin G-associated kinase (GAK) is a protein involved in cellular processes such as regulation of the cell cycle and signal transduction. It has an approximate mass of 148 kDa. NKIAMRE is expressed in various tissues including the brain heart and kidneys. This protein has kinase activity which allows it to phosphorylate other proteins influencing their function and activity in cells.
Biological function summary

NKIAMRE modulates cell growth and differentiation. While not identified as part of a specific complex it interacts with several proteins implicating it in cellular signaling networks. These interactions suggest it has roles in managing intracellular signaling pathways affecting how cells respond to various external and internal signals. It is especially relevant in maintaining the normal functioning of cells.

Pathways

NKIAMRE interacts closely with cell cycle and signal transduction pathways. It participates directly in the regulation of the cell cycle where it affects the progression of cells through different phases of cell division. Cyclin-dependent kinases (CDKs) function alongside NKIAMRE in this regard coordinating cell cycle regulation. Additionally NKIAMRE's involvement in signal transduction connects it to the MAPK signaling pathway an important route in conveying extracellular signals to the cellular machinery.

NKIAMRE links closely with certain cancers and neurodegenerative diseases. Abnormal expression of this protein correlates with the progression of some cancer types where it affects cell proliferation and survival. Also its role in the brain environment highlights relevance in conditions like Alzheimer's disease. Aberrant interactions between NKIAMRE and tau protein a major factor in Alzheimer's suggest a significant link with disease pathogenesis. Understanding NKIAMRE's functions and interactions could unravel more about its role in these diseases.
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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

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Product protocols

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Target data

See full target information CDKL3
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