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AB124599

Recombinant Human NKIRAS2 protein

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Recombinant Human NKIRAS2 protein is a Human Full Length protein, in the 1 to 191 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

KBRAS2, NKIRAS2, NF-kappa-B inhibitor-interacting Ras-like protein 2, I-kappa-B-interacting Ras-like protein 2, Kappa B-Ras protein 2, KappaB-Ras2

1 Images
SDS-PAGE - Recombinant Human NKIRAS2 protein (AB124599)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human NKIRAS2 protein (AB124599)

15% SDS-PAGE showing ab124599 (3µg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9NYR9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMGKSCKVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYVGSIETDRGVREQVRFYDTRGLRDGAELPRHCFSCTDGYVLVYSTDSRESFQRVELLKKEIDKSKDKKEVTIVVLGNKCDLQEQRRVDPDVAQHWAKSEKVKLWEVSVADRRSLLEPFVYLASKMTQPQSKSAFPLSRKNKGSGSLDG","proteinLength":"Full Length","predictedMolecularWeight":"24 kDa","actualMolecularWeight":null,"aminoAcidEnd":191,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NYR9","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NKIRAS2 also known as Nuclear factor kappa B Inhibitor-interacting Ras-like protein 2 is a protein with estimated molecular mass around 21 kDa. This protein acts as a negative regulator of NF-kB signaling pathways by preventing the phosphorylation and degradation of IkB proteins. It serves as a molecular switch in the inhibition of Ras-related proteins and shows expression in various tissues notably in immune cells and the brain.
Biological function summary

NKIRAS2 functions to modulate inflammatory responses and immune regulation. It is observed interacting within a larger complex that includes NF-kB and IkB proteins. By binding to these molecules NKIRAS2 plays a role in controlling the activation of transcription factors important for immune and stress response pathways. This modulation prevents excessive immune responses and maintains cellular homeostasis.

Pathways

NKIRAS2 involvement is most noted in the NF-kB signaling pathway which is essential for immune response regulation and the Ras signaling pathway contributing to the regulation of cell proliferation and survival. NKIRAS2 acts in coordination with proteins like IkB and Ras family members to modulate the activity of these signaling pathways. This interaction helps finely tune cellular responses to external stimuli protecting cells from unwarranted activation.

NKIRAS2 has links to inflammatory diseases and certain types of cancer. Its role in the inhibition of NF-kB pathways makes it a point of interest in pathologies where this signaling becomes dysregulated. Deregulation of NKIRAS2 or its interacting partners such as IkB proteins can lead to chronic inflammation and has associations with cancers where NF-kB signaling is aberrantly activated. Research into these pathways could potentially lead to novel therapeutic strategies.
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Specifications

Form

Liquid

Additional notes

ab124599 is purified by using conventional chromatography techniques.

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General info

Function

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).

Sequence similarities

Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

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Product protocols

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Target data

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).
See full target information NKIRAS2
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Product promise

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