Recombinant Human NLGN4X protein (His tag) is a Human Fragment protein, in the 1 to 676 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M S R P Q G L L W L P L L F T P V C V M L N S N V L L W L T A L A I K F T L I D S Q A Q Y P V V N T N Y G K I R G L R T P L P N E I L G P V E Q Y L G V P Y A S P P T G E R R F Q P P E P P S S W T G I R N T T Q F A A V C P Q H L D E R S L L H D M L P I W F T A N L D T L M T Y V Q D Q N E D C L Y L N I Y V P T E D D I H D Q N S K K P V M V Y I H G G S Y M E G T G N M I D G S I L A S Y G N V I V I T I N Y R L G I L G F L S T G D Q A A K G N Y G L L D Q I Q A L R W I E E N V G A F G G D P K R V T I F G S G A G A S C V S L L T L S H Y S E G L F Q K A I I Q S G T A L S S W A V N Y Q P A K Y T R I L A D K V G C N M L D T T D M V E C L R N K N Y K E L I Q Q T I T P A T Y H I A F G P V I D G D V I P D D P Q I L M E Q G E F L N Y D I M L G V N Q G E G L K F V D G I V D N E D G V T P N D F D F S V S N F V D N L Y G Y P E G K D T L R E T I K F M Y T D W A D K E N P E T R R K T L V A L F T D H Q W V A P A V A T A D L H A Q Y G S P T Y F Y A F Y H H C Q S E M K P S W A D S A H G D E V P Y V F G I P M I G P T E L F S C N F S K N D V M L S A V V M T Y W T N F A K T G D P N Q P V P Q D T K F I H T K P N R F E E V A W S K Y N P K D Q L Y L H I G L K P R V R D H Y R A T K V A F W L E L V P H L H N L N E I F Q Y V S T T T K V P P P D M T S F P Y G T R R S P A K I W P T T K R P A I T P A N N P K H S K D P H K T G P E D T T V L I E T K R D Y S T E L S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members.
Alternative names
KIAA1260, NLGN4, UNQ365/PRO701, NLGN4X, Neuroligin X, HNLX
Recommended products
Recombinant Human NLGN4X protein (His tag) is a Human Fragment protein, in the 1 to 676 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q8N0W4-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M S R P Q G L L W L P L L F T P V C V M L N S N V L L W L T A L A I K F T L I D S Q A Q Y P V V N T N Y G K I R G L R T P L P N E I L G P V E Q Y L G V P Y A S P P T G E R R F Q P P E P P S S W T G I R N T T Q F A A V C P Q H L D E R S L L H D M L P I W F T A N L D T L M T Y V Q D Q N E D C L Y L N I Y V P T E D D I H D Q N S K K P V M V Y I H G G S Y M E G T G N M I D G S I L A S Y G N V I V I T I N Y R L G I L G F L S T G D Q A A K G N Y G L L D Q I Q A L R W I E E N V G A F G G D P K R V T I F G S G A G A S C V S L L T L S H Y S E G L F Q K A I I Q S G T A L S S W A V N Y Q P A K Y T R I L A D K V G C N M L D T T D M V E C L R N K N Y K E L I Q Q T I T P A T Y H I A F G P V I D G D V I P D D P Q I L M E Q G E F L N Y D I M L G V N Q G E G L K F V D G I V D N E D G V T P N D F D F S V S N F V D N L Y G Y P E G K D T L R E T I K F M Y T D W A D K E N P E T R R K T L V A L F T D H Q W V A P A V A T A D L H A Q Y G S P T Y F Y A F Y H H C Q S E M K P S W A D S A H G D E V P Y V F G I P M I G P T E L F S C N F S K N D V M L S A V V M T Y W T N F A K T G D P N Q P V P Q D T K F I H T K P N R F E E V A W S K Y N P K D Q L Y L H I G L K P R V R D H Y R A T K V A F W L E L V P H L H N L N E I F Q Y V S T T T K V P P P D M T S F P Y G T R R S P A K I W P T T K R P A I T P A N N P K H S K D P H K T G P E D T T V L I E T K R D Y S T E L S
- Accession
- Q8N0W4
- Protein length
- Fragment
- Predicted molecular weight
- 72.9 kDa
- Amino acids
- 1 to 676
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members.
- Sequence similarities
Belongs to the type-B carboxylesterase/lipase family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
NLGN4X also known as neuroligin 4X is a protein that plays a critical role in synaptic function and signaling in the human brain. This protein with a molecular mass of approximately 91 kDa is part of the neuroligin family which includes several proteins integral to the formation and maintenance of synapses. It is predominantly expressed in the central nervous system particularly in areas where neuronal communication is essential. NLGN4X assists in the important task of cell–cell interaction at synaptic junctions promoting synaptic stability and ensuring efficient neurotransmission.
- Biological function summary
NLGN4X participates in the maintenance of synaptic function both in excitatory and inhibitory synapses. It forms part of a larger synaptic complex that includes neurexins and other proteins essential for synaptic adhesion and signal transduction. These complexes are necessary for precise neurotransmitter release and reception allowing neurons to reliably and efficiently communicate. The structural integrity provided by NLGN4X's presence in these complexes underlies normal synaptic operation and influences cognitive processes.
- Pathways
Neuroligins belong to multiple neurological pathways emphasizing their role in synaptic organization and plasticity. NLGN4X engages with pathways like the synaptic vesicle cycle and postsynaptic density dynamics vital for modulating synaptic strength and plasticity. Through these pathways NLGN4X interacts closely with proteins such as neurexins facilitating synaptic organization and communication that are fundamental in neural network function.
- Associated diseases and disorders
Alterations in NLGN4X are strongly associated with autism spectrum disorders and intellectual disability. Mutations or deletions within the NLGN4X gene can disrupt normal synaptic connectivity leading to impaired social behavior and cognitive functions inherent in these disorders. NLGN4X is intertwined with other proteins such as SHANK3 both linked to synaptic stability and function. Disruption in their interactions can exacerbate synaptic and functional deficits observed in these conditions.
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SDS-PAGE - Recombinant Human NLGN4X protein (His tag) (ab276677)
SDS-PAGE analysis of ab276677
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