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AB276677

Recombinant Human NLGN4X protein (His tag)

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Recombinant Human NLGN4X protein (His tag) is a Human Fragment protein, in the 1 to 676 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

KIAA1260, NLGN4, UNQ365/PRO701, NLGN4X, Neuroligin X, HNLX

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SDS-PAGE - Recombinant Human NLGN4X protein (His tag) (AB276677)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human NLGN4X protein (His tag) (AB276677)

SDS-PAGE analysis of ab276677

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8N0W4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELS","proteinLength":"Fragment","predictedMolecularWeight":"72.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":676,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q8N0W4","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NLGN4X also known as neuroligin 4X is a protein that plays a critical role in synaptic function and signaling in the human brain. This protein with a molecular mass of approximately 91 kDa is part of the neuroligin family which includes several proteins integral to the formation and maintenance of synapses. It is predominantly expressed in the central nervous system particularly in areas where neuronal communication is essential. NLGN4X assists in the important task of cell–cell interaction at synaptic junctions promoting synaptic stability and ensuring efficient neurotransmission.
Biological function summary

NLGN4X participates in the maintenance of synaptic function both in excitatory and inhibitory synapses. It forms part of a larger synaptic complex that includes neurexins and other proteins essential for synaptic adhesion and signal transduction. These complexes are necessary for precise neurotransmitter release and reception allowing neurons to reliably and efficiently communicate. The structural integrity provided by NLGN4X's presence in these complexes underlies normal synaptic operation and influences cognitive processes.

Pathways

Neuroligins belong to multiple neurological pathways emphasizing their role in synaptic organization and plasticity. NLGN4X engages with pathways like the synaptic vesicle cycle and postsynaptic density dynamics vital for modulating synaptic strength and plasticity. Through these pathways NLGN4X interacts closely with proteins such as neurexins facilitating synaptic organization and communication that are fundamental in neural network function.

Alterations in NLGN4X are strongly associated with autism spectrum disorders and intellectual disability. Mutations or deletions within the NLGN4X gene can disrupt normal synaptic connectivity leading to impaired social behavior and cognitive functions inherent in these disorders. NLGN4X is intertwined with other proteins such as SHANK3 both linked to synaptic stability and function. Disruption in their interactions can exacerbate synaptic and functional deficits observed in these conditions.
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Specifications

Form

Lyophilized

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General info

Function

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members.

Sequence similarities

Belongs to the type-B carboxylesterase/lipase family.

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Product protocols

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Target data

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members.
See full target information NLGN4X
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Complementary Products

Primary Antibodies

AB181251

Anti-Neuroligin 1 + Neuroligin 4 antibody [EPR13108]

RabMAb|Recombinant

Western blot - Anti-Neuroligin 1 + Neuroligin 4 antibody [EPR13108] (AB181251)

  • 0
  • 0
Cell Lines & Lysates

AB264783

Human NLGN4X knockout HeLa cell line

Sanger Sequencing - Human NLGN4X knockout HeLa cell line (AB264783)

  • 0
  • 0
Cell Lines & Lysates

AB263279

Human NLGN4X knockout HeLa cell lysate

Sanger Sequencing - Human NLGN4X knockout HeLa cell lysate (AB263279)

  • 0
  • 0

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