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AB161181

Recombinant Human NMU protein (GST tag N-Terminus)

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Recombinant Human NMU protein (GST tag N-Terminus) is a Human Full Length protein, in the 36 to 174 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Neuromedin-U, NMU

1 Images
SDS-PAGE - Recombinant Human NMU protein (GST tag N-Terminus) (AB161181)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human NMU protein (GST tag N-Terminus) (AB161181)

ab161181 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

P48645

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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SDS-PAGE - Recombinant Human ZNF358 protein (GST tag N-Terminus) (AB165455)

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Primary Antibodies

AB229635

Anti-NMU antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMU antibody (AB229635)

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AB164919

Recombinant Human Zinc finger protein 276 (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Zinc finger protein 276 (GST tag N-Terminus) (AB164919)

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AB166020

Recombinant Human YTHDF3 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human YTHDF3 protein (GST tag N-Terminus) (AB166020)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"CRGAPILPQGLQPEQQLQLWNEIDDTCSSFLSIDSQPQASNALEELCFMIMGMLPKPQEQDEKDNTKRFLFHYSKTQKLGKSNVVSSVVHPLLQLVPHLHERRMKRFRVDEEFQSPFASQSRGYFLFRPRNGRRSAGFI","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":174,"aminoAcidStart":36,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P48645","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neuromedin U (NMU) is a regulatory peptide known for its role in modulating smooth muscle contraction and energy homeostasis. Alternate names include neuromedin reflecting its original discovery in the spinal cord. NMU has a molecular mass ranging between 2392 and 2583 Da depending on the variant. It is expressed predominantly in the gastrointestinal tract and central nervous system influencing various physiological processes within these tissues.
Biological function summary

NMU functions significantly within the nervous and endocrine systems. It is an important part of the larger neuromedin peptide family. NMU interacts with specific receptors NMU-R1 and NMU-R2 to mediate biological effects. Within the body NMU influences feeding behavior circadian rhythms and stress response mechanisms demonstrating its integral role in maintaining physiological balance.

Pathways

NMU integrates into hormonal and neuroendocrine signaling routes. The peptide participates in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis influencing stress responses. Its action also intersects the energy metabolism pathway interacting with proteins such as ghrelin and leptin. These interactions position NMU as an important player in energy intake control and stress regulation.

NMU has implications in obesity and inflammatory diseases. Abnormally high or low levels can contribute to metabolic disorders indicating its central role in energy balance and metabolic health. NMU's connection to the HPA axis associates it with proteins like corticotropin-releasing hormone which impacts inflammatory processes. Exploring NMU's involvement could unveil new therapeutic strategies for managing these conditions.
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Specifications

Form

Liquid

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General info

Function

Neuromedin-U-25. Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.. Neuromedin precursor-related peptide 33. Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.. Neuromedin precursor-related peptide 36. Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.

Sequence similarities

Belongs to the NmU family.

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Product protocols

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Target data

Neuromedin-U-25. Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.. Neuromedin precursor-related peptide 33. Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.. Neuromedin precursor-related peptide 36. Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.
See full target information NMU
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