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AB171677

Recombinant Human NOB1 protein (denatured) (His tag N-Terminus)

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Recombinant Human NOB1 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 412 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.

View Alternative Names

ART4, NOB1P, PSMD8BP1, MSTP158, NOB1, RNA-binding protein NOB1, Phosphorylation regulatory protein HP-10, Protein ART-4

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SDS-PAGE - Recombinant Human NOB1 protein (denatured) (His tag N-Terminus) (AB171677)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human NOB1 protein (denatured) (His tag N-Terminus) (AB171677)

15% SDS-PAGE analysis of ab171677 (3µg).

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9ULX3

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAPVEHVVADAGAFLRHAALQDIGKNIYTIREVVTEIRDKATRRRLAVLPYELRFKEPLPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPQKVKVSSSIQHPETPLHISGFHLPYKPKPPQETEKGHSACEPENLEFSSFMFWRNPLPNIDHELQELLIDRGEDVPSEEEEEEENGFEDRKDDSDDDGGGWITPSNIKQIQQELEQCDVPEDVRVGCLTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCSHCGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSQKARQKTNVFAPDYIAGVSPFVENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR","proteinLength":"Full Length","predictedMolecularWeight":"49.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":412,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9ULX3","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Nucleolar protein 1 (NOB1) plays an important role in ribosomal RNA processing and biogenesis. Often referred to as NOB1p it is a protein that weighs approximately 55 kDa. NOB1 is expressed mainly in the nucleolus. This protein contains several domains such as the PIN domain which is important in its RNA cleavage function.
Biological function summary

NOB1 functions as a part of a complex called the 26S proteasome regulatory complex. It participates in the maturation of the 20S proteasome facilitating the processing of 18S rRNA which is important for ribosome assembly. This role highlights its importance for maintaining ribosomal function and protein synthesis.

Pathways

NOB1's role in ribosome assembly ties it to the ribosome biogenesis and protein synthesis pathways. It works closely with proteins such as PNO1 and the 18S rRNA processing machinery. These interactions ensure that ribosomes are properly assembled and functional which is critical for cellular growth and division.

Mutations or dysregulation of NOB1 have implications in cancer development. Aberrant expression of NOB1 has been linked to tumorigenesis particularly in pathways involving the oncogenic protein MYC. By influencing ribosome biogenesis NOB1 can contribute to the uncontrolled proliferation characteristic of cancer cells.
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Specifications

Form

Liquid

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General info

Function

May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).

Sequence similarities

Belongs to the NOB1 family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).
See full target information NOB1
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Complementary Products

Primary Antibodies

AB224619

Anti-NOB1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NOB1 antibody (AB224619)

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