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AB161548

Recombinant Human Norbin protein (GST tag N-Terminus)

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(1 Publication)

Recombinant Human Norbin protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 729 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KIAA0607, NCDN, Neurochondrin

1 Images
SDS-PAGE - Recombinant Human Norbin protein (GST tag N-Terminus) (AB161548)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Norbin protein (GST tag N-Terminus) (AB161548)

ab161548 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9UBB6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Proteins & Peptides

AB159808

Recombinant Human ZAN protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZAN protein (GST tag N-Terminus) (AB159808)

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Primary Antibodies

AB88877

Anti-Norbin antibody

Western blot - Anti-Norbin antibody (AB88877)

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  • 1
Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Proteins & Peptides

AB163077

Recombinant Human VNN3 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human VNN3 protein (GST tag N-Terminus) (AB163077)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSCCDLAAAGQLGKASIMASDCEPALNQAEGRNPTLERYLGALREAKNDSEQFAALLLVTKAVKAGDIDAKTRRRIFDAVGFTFPNRLLTTKEAPDGCPDHVLRALGVALLACFCSDPELAAHPQVLNKIPILSTFLTARGDPDDAARRSMIDDTYQCLTAVAGTPRGPRHLIAGGTVSALCQAYLGHGYGFDQALALLVGLLAAAETQCWKEAEPDLLAVLRGLSEDFQKAEDASKFELCQLLPLFLPPTTVPPECYRDLQAGLARILGSKLSSWQRNPALKLAARLAHACGSDWIPAGSSGSKFLALLVNLACVEVRLALEETGTEVKEDVVTACYALMELGIQECTRCEQSLLKEPQKVQLVSVMKEAIGAVIHYLLQVGSEKQKEPFVFASVRILGAWLAEETSSLRKEVCQLLPFLVRYAKTLYEEAEEANDLSQQVANLAISPTTPGPTWPGDALRLLLPGWCHLTVEDGPREILIKEGAPSLLCKYFLQQWELTSPGHDTSVLPDSVEIGLQTCCHIFLNLVVTAPGLIKRDACFTSLMNTLMTSLPALVQQQGRLLLAANVATLGLLMARLLSTSPALQGTPASRGFFAAAILFLSQSHVARATPGSDQAVLALSPEYEGIWADLQELWFLGMQAFTGCVPLLPWLAPAALRSRWPQELLQLLGSVSPNSVKPEMVAAYQGVLVELARANRLCREAMRLQAGEETASHYRMAALEQCLSEP","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":729,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9UBB6","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Norbin also known as neurochondrin is a protein with a mass of approximately 80 kDa. It is expressed widely in the central nervous system with significant levels present in neurons. Norbin plays a mechanical role by interacting directly with various signaling proteins acting as an anchor within cell signaling frameworks. The interactions help regulate multiple cellular processes important for neuronal function and communication indicating Norbin's significance in neurophysiological activities.
Biological function summary

The actions of proteins within the cell often influence cellular signaling and communication. Norbin is a part of several protein complexes assisting in the regulation of signal transduction pathways particularly those involving G-protein-coupled receptors (GPCRs). These interactions highlight Norbin's role in maintaining synaptic function and neuronal excitability. Norbin also affects synaptic plasticity contributing to learning and memory processes by modulating neurotransmission efficiency.

Pathways

Various signaling processes within cells are interlinked and Norbin integrates into the calcium signaling and MAPK pathways. In these pathways Norbin interacts closely with proteins like mGluR5 (a type of metabotropic glutamate receptor) to mediate downstream effects on neuronal activity and development. This association impacts cellular processes by controlling cellular responses to environmental stimuli thereby affecting overall nervous system functionality.

Proteins and pathways often correlate with specific conditions. Norbin's involvement with neurophysiological pathways links it to neurological disorders such as schizophrenia and Alzheimer's disease. During disease states altered Norbin expression or dysregulation may impact its interaction with proteins like mGluR5 exacerbating symptoms or progression of these conditions. Research into Norbin's role offers potential therapeutic insights into these neurological disorders.
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Specifications

Form

Liquid

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General info

Function

Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed : 33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable).

Sequence similarities

Belongs to the neurochondrin family.

Post-translational modifications

Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7.

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Product protocols

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Target data

Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed : 33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable).
See full target information NCDN
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Neurology(R) neuroimmunology & neuroinflammation 6: PubMed31511329

2019

Neurochondrin neurological autoimmunity.

Applications

Unspecified application

Species

Unspecified reactive species

Shahar Shelly,Thomas J Kryzer,Lars Komorowski,Ramona Miske,Mark D Anderson,Eoin P Flanagan,Shannon R Hinson,Vanda A Lennon,Sean J Pittock,Andrew McKeon
View all publications
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