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AB161166

Recombinant Human NOXA1 protein (GST tag N-Terminus)

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Recombinant Human NOXA1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 483 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

P51NOX, NOXA1, NADPH oxidase activator 1, NOX activator 1, Antigen NY-CO-31, NCF2-like protein, P67phox-like factor, p51-nox

1 Images
SDS-PAGE - Recombinant Human NOXA1 protein (GST tag N-Terminus) (AB161166)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human NOXA1 protein (GST tag N-Terminus) (AB161166)

ab161166 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q86UR1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MASLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLAGDPEAALRAFDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQAWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEGSLNGLDSALDQVQRRGSLPPRQVPRGEVFRPHRWHLKHLEPVDFLGKAKVVASAIPDDQGWGVRPQQPQGPGANHDARSLIMDSPRAGTHQGPLDAETEVGADRCTSTAYQEQRPQVEQVGKQAPLSPGLPAMGGPGPGPCEDPAGAGGAGAGGSEPLVTVTVQCAFTVALRARRGADLSSLRALLGQALPHQAQLGQLSYLAPGEDGHWVPIPEEESLQRAWQDAAACPRGLQLQCRGAGGRPVLYQVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGPRMSGAPGRLPRSQQGDQP","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":483,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q86UR1","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NOXA1 also known as NADPH oxidase activator 1 functions as an important regulatory component in the assembly and activation of the NADPH oxidase complex. This protein has a mass of approximately 57 kDa. It is usually expressed in various tissues including the pancreas and lung indicating its diverse role in physiological processes. NOXA1 works by facilitating the production of reactive oxygen species (ROS) through stimulating the activity of NADPH oxidase an important action for cellular signaling and defense.
Biological function summary

The NOXA1 protein interacts in the complex environment of intracellular processes. It forms part of the NADPH oxidase complex influencing ROS generation which plays a role in cell signaling microbial killing and maintaining vascular tone. Through these functions NOXA1 contributes to normal and pathological conditions by promoting oxidative stress ultimately affecting both immune responses and cellular communications.

Pathways

NOXA1 associates significantly with the superoxide production pathway through its action in NADPH oxidase complexes. It interacts closely with proteins like p67phox and p47phox important for proper complex activation and function. NOXA1 also participates in the signaling pathway related to inflammation where it modulates the immune response alongside proteins such as Rac1 and Rac2. These interactions place NOXA1 in key regulatory roles within these biological pathways.

NOXA1 links to various oxidative stress-related conditions. For example chronic granulomatous disease features dysfunctional NADPH oxidase activity in which NOXA1's proper function is compromised. Additionally NOXA1 exhibits connections to cardiovascular disorders as its role in producing reactive oxygen species can exacerbate oxidative damage contributing to disease progression. Proteins like gp91phox are also involved in these conditions highlighting NOXA1's significance in these contexts.
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Specifications

Form

Liquid

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General info

Function

Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.

Sequence similarities

Belongs to the NCF2/NOXA1 family.

Post-translational modifications

Interaction with YWHAZ depends on phosphorylation by PKA.

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Product protocols

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Target data

Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
See full target information NOXA1
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