Recombinant Human NPDC1 protein (His tag) is a Human Fragment protein, in the 1 to 181 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M A T P L P P P S P R H L R L L R L L L S G L V L G A A L R G A A A G H P D V A A C P G S L D C A L K R R A R C P P G A H A C G P C L Q P F Q E D Q Q G L C V P R M R R P P G G G R P Q P R L E D E I D F L A Q E L A R K E S G H S T P P L P K D R Q R L P E P A T L G F S A R G Q G L E L G L P S T P G T P T P T P H T S L G S P V S S D P V H M S P L E P R G G Q G D
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).
Alternative names
Neural proliferation differentiation and control protein 1, NPDC-1, NPDC1
Recommended products
Recombinant Human NPDC1 protein (His tag) is a Human Fragment protein, in the 1 to 181 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9NQX5-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M A T P L P P P S P R H L R L L R L L L S G L V L G A A L R G A A A G H P D V A A C P G S L D C A L K R R A R C P P G A H A C G P C L Q P F Q E D Q Q G L C V P R M R R P P G G G R P Q P R L E D E I D F L A Q E L A R K E S G H S T P P L P K D R Q R L P E P A T L G F S A R G Q G L E L G L P S T P G T P T P T P H T S L G S P V S S D P V H M S P L E P R G G Q G D
- Accession
- Q9NQX5
- Protein length
- Fragment
- Predicted molecular weight
- 16.9 kDa
- Amino acids
- 1 to 181
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).
- Sequence similarities
Belongs to the NPDC1/cab-1 family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
NPDC1 also known as Neural Proliferation Differentiation and Control protein 1 is a protein involved in inhibiting cell proliferation. It has a molecular mass of approximately 38 kDa. This protein finds expression mainly in the central nervous system particularly within neurons and shows variations in expression depending on developmental stage and cellular context. Its functional involvement in regulating cell cycle and neural differentiation makes it a significant player in neural development.
- Biological function summary
NPDC1 plays a critical role in controlling the cell cycle and promoting neural differentiation. It does not typically form part of a large complex but it interacts with various molecules to execute its functions. NPDC1 helps modulate the activity of the retinoblastoma (Rb) pathway which is important for controlling cell cycle progression and differentiation. By regulating this pathway NPDC1 can influence cellular transformation events and maintain cellular homeostasis.
- Pathways
NPDC1 significantly impacts neural cell cycle regulation and differentiation pathways. It strongly associates with the Rb pathway thereby impacting cell cycle checkpoints and differentiation signals. NPDC1 also shows interaction with proteins such as E2F transcription factors which play an important role in driving progression through the cell cycle. Its involvement in these pathways highlights its importance in maintaining proper neural development and growth.
- Associated diseases and disorders
NPDC1 shows potential relevance in neurological disorders and cancer. Aberrant expression or dysregulation of NPDC1 can lead to conditions such as neurodegenerative diseases including Alzheimer's disease where neural cell cycle control is disrupted. Additionally its interaction with Rb protein connects it to cancer pathways suggesting its potential involvement in gliomas and other neural-derived tumors. Understanding NPDC1's function and regulation can provide critical insights into these diseases and aid in developing targeted therapeutic strategies.
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1 product image
SDS-PAGE - Recombinant Human NPDC1 protein (His tag) (ab276575)
SDS-PAGE analysis of ab276575
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