JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB160962

Recombinant Human NPM2 protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human NPM2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 214 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Nucleoplasmin-2, NPM2

1 Images
SDS-PAGE - Recombinant Human NPM2 protein (GST tag N-Terminus) (AB160962)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human NPM2 protein (GST tag N-Terminus) (AB160962)

ab160962 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q86SE8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Complementary Products

Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

  • 0
  • 0
Primary Antibodies

AB243544

Anti-NPM2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPM2 antibody (AB243544)

  • 4
  • 1
Proteins & Peptides

AB162411

Recombinant Human MSY2/YBOX2/YBX2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human MSY2/YBOX2/YBX2 protein (GST tag N-Terminus) (AB162411)

  • 0
  • 0
Proteins & Peptides

AB162402

Recombinant Human Zinc finger protein 691 (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Zinc finger protein 691 (GST tag N-Terminus) (AB162402)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMHRVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQERYEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKKLEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":214,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q86SE8","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Nucleophosmin/Nucleoplasmin 2 (NPM2) also referred to as Nucleoplasmin-2 is a protein with molecular mass approximately 22 kDa. It belongs to the family of nucleoplasmins which are chromatin remodeling proteins. NPM2 is mainly expressed in oocytes and plays a significant role during early embryonic development. The protein is highly localized in the nuclei of developing oocytes and is known for its capacity to bind and exchange histones which is essential for chromatin structure.
Biological function summary

The function of NPM2 involves regulating chromatin in germ cells and early embryogenesis. It acts as a histone chaperone forming complexes with histones to facilitate chromatin assembly and disassembly. The protein enables the proper packing and unpacking of DNA ensuring genomic stability during cell division. NPM2 does not work alone and it often forms a complex with histone proteins allowing it to modulate chromatin dynamics efficiently.

Pathways

NPM2 participates in key cellular processes related to chromatin remodeling and regulation. It plays an important role in the chromatin assembly pathway working alongside proteins like histone H1 to modulate DNA accessibility. Additionally NPM2 interacts with other histone chaperones affecting the nucleosome assembly pathway. Through these pathways it influences various nuclear processes important for gene expression and maintenance of nuclear architecture.

NPM2 is associated with issues in reproductive health and cancer. Abnormal expression or malfunction of NPM2 can lead to infertility due to defects in oocyte maturation. In cancer biology variations in NPM2 expression levels might correlate with tumor progression where it interacts with several oncogenic proteins. For example changes in the function of NPM2 might influence the activity of histone-modifying enzymes linked to chromatin changes seen in malignant cells.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.

Sequence similarities

Belongs to the nucleoplasmin family.

Subcellular localisation

Nucleus

style
left-column

Product protocols

style
left-column

Target data

Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.
See full target information NPM2
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com