Recombinant Human NPR-A protein (Tagged)
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Recombinant Human NPR-A protein (Tagged) is a Human Fragment protein, in the 33 to 473 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
ANPRA, NPR1, Atrial natriuretic peptide receptor 1, Atrial natriuretic peptide receptor type A, Guanylate cyclase A, ANP-A, ANPR-A, NPR-A, GC-A
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human NPR-A protein (Tagged) (AB235810)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab235810 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) NPR-A
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human NPR-A protein (Tagged) (AB235810)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab235810 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) NPR-A.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human NPR-A protein (Tagged) (AB235810)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab235810.
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Natriuretic peptide receptor A plays a significant role in cardiovascular homeostasis. NPR-A is not part of a larger complex but works closely with other natriuretic peptide systems to regulate blood pressure electrolyte balance and fluid homeostasis. Its activation results in diuresis natriuresis and vasodilation contributing to its function in maintaining cardiovascular health. Efficient functioning of NPR-A is essential for modulating cardiovascular responses.
Pathways
NPR-A is important in the cyclic GMP pathway and the ANP signaling pathway. It interacts with proteins like NPR-C and soluble guanylyl cyclase modulating key physiological responses. NPR-A impacts smooth muscle relaxation and renal function by influencing cGMP levels and related downstream pathways. Its role within these pathways is fundamental to maintaining vascular tone and sodium excretion.
Specifications
Form
Liquid
General info
Function
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Post-translational modifications
Phosphorylation of the protein kinase-like domain is required for full activation by ANP.
Target data
Complementary Products
Product promise
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