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AB276693

Recombinant Human NPTN protein (His tag)

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Recombinant Human NPTN protein (His tag) is a Human Fragment protein, in the 1 to 221 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

SDFR1, SDR1, NPTN, Neuroplastin, Stromal cell-derived receptor 1, SDR-1

1 Images
SDS-PAGE - Recombinant Human NPTN protein (His tag) (AB276693)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human NPTN protein (His tag) (AB276693)

SDS-PAGE analysis of ab276693

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9Y639

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Complementary Products

Proteins & Peptides

AB276403

Recombinant Human VSIG2 protein (His tag)

SDS-PAGE - Recombinant Human VSIG2 protein (His tag) (AB276403)

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Primary Antibodies

AB272652

Anti-NPTN antibody

Western blot - Anti-NPTN antibody (AB272652)

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  • 0
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
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Proteins & Peptides

AB181905

Recombinant Human ZCCHC12 protein (denatured)

SDS-PAGE - Recombinant Human ZCCHC12 protein (denatured) (AB181905)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSGSSLPSALALSLLLVSGSLLPGPGAAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHL","proteinLength":"Fragment","predictedMolecularWeight":"23.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":221,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9Y639","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neuroplastin (NPTN) also known as Basigin-like protein 1 plays an important role in various cellular functions. This protein has a mass of approximately 34 kDa as determined by its amino acid sequence. NPTN locates itself on the cell membrane and exhibits expression in multiple tissues especially in the nervous system and skeletal muscles. This protein is known for participating actively in cell adhesion processes which influence neural development and synaptic plasticity.
Biological function summary

Neuroplastin contributes to important cellular processes like calcium homeostasis and synapse formation. As part of the oligomeric receptor complex it facilitates calcium-mediated signaling by forming functional partnerships with other membrane proteins such as plasma membrane Ca2+ ATPases. Neuroplastin's interactions influence dendritic spine morphology and synaptic strength which are essential for proper neuronal communication and memory formation.

Pathways

Neuroplastin functions significantly in the Calcium signaling pathway which regulates numerous cellular activities including muscle contraction and neurotransmitter release. It associates with proteins like PMCA playing a role in calcium ion efflux and maintaining intracellular calcium concentration. Additionally Neuroplastin is involved in the MAP kinase signaling pathway which contributes to cell viability and adaptation to stress.

Neuroplastin shows linkage to conditions such as schizophrenia and hearing loss. Abnormal expression or mutations of NPTN can disrupt neural connectivity and synaptic functions potentially leading to psychiatric disorders. Furthermore studies associate NPTN with Basigin in disorders affecting auditory capacities suggesting possible therapeutic targets for intervention in inner ear function deficits.
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Specifications

Form

Lyophilized

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General info

Function

Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed : 30190470). Promotes localization of XKR8 at the cell membrane (PubMed : 27503893).

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Product protocols

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Target data

Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed : 30190470). Promotes localization of XKR8 at the cell membrane (PubMed : 27503893).
See full target information NPTN
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