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AB152580

Recombinant Human NPY2R/Y2 receptor protein

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Recombinant Human NPY2R/Y2 receptor protein is a Human Full Length protein, in the 1 to 381 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

Neuropeptide Y receptor type 2, NPY2-R, NPY-Y2 receptor, Y2 receptor, NPY2R

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, SDS-PAGE, WB

applications

Biologically active

No

Accession

P49146

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as NPY2R.
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Sequence info

[{"sequence":"MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV","proteinLength":"Full Length","predictedMolecularWeight":"69.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":381,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P49146","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The NPY2R also known as the Y2 receptor is a G-protein coupled receptor with a molecular mass of approximately 42 kDa. It primarily binds neuropeptide Y (NPY) peptide YY (PYY) and pancreatic polypeptide (PP). The NPY2R is expressed in the central nervous system particularly in the brain regions like the hypothalamus and hippocampus as well as in peripheral tissues such as vascular smooth muscle and the gastrointestinal tract.
Biological function summary

The NPY2R is involved in processes like appetite regulation anxiety and blood pressure control. When activated by its ligands NPY2R plays a role in reducing neurotransmitter release which translates into modulation of neuronal activity and vascular tone. It does not form part of a larger complex but functions by itself to exert its biological roles.

Pathways

NPY2R participates in the neuropeptide signaling pathway and is linked to the regulation of energy homeostasis. Through its interactions NPY2R influences the action of other receptors such as the Y1 receptor both contributing to the complex regulation of food intake and stress responses. The Y2 receptor also affects the sympathetic nervous system through the modulation of noradrenaline release.

NPY2R shows a connection with obesity and hypertension. Abnormal Y2 receptor function could lead to disrupted energy balance and increased appetite contributing to obesity. In hypertension altered NPY2R activity may lead to dysfunctional blood pressure regulation. Connections with proteins like Y1 receptor also underpin its relevance in these conditions as they together orchestrate the cardiovascular and metabolic responses.
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Specifications

Form

Liquid

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General info

Function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Product protocols

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Target data

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
See full target information NPY2R
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