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AB132113

Recombinant Human NPY5R protein

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Recombinant Human NPY5R protein is a Human Full Length protein, in the 1 to 445 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

NPYR5, NPY5R, Neuropeptide Y receptor type 5, NPY5-R, NPY-Y5 receptor, NPYY5-R, Y5 receptor

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SDS-PAGE - Recombinant Human NPY5R protein (AB132113)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human NPY5R protein (AB132113)

12.5% SDS-PAGE analysis of ab132113, stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

Tag free

Applications

WB, ELISA, SDS-PAGE

applications

Biologically active

No

Accession

Q15761

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Y5 receptor.
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Sequence info

[{"sequence":"MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM","proteinLength":"Full Length","predictedMolecularWeight":"74.69 kDa","actualMolecularWeight":null,"aminoAcidEnd":445,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q15761","tags":[]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NPY5R also known as the Neuropeptide Y receptor Y5 plays an important role in the human body. It is a G-protein-coupled receptor with a molecular weight around 50 kDa. NPY5R is mainly expressed in the central nervous system especially in the hypothalamus. This receptor is one of several receptors that bind to the neuropeptide Y (NPY) peptide YY (PYY) and pancreatic polypeptide (PP) which are involved in various physiological processes.
Biological function summary

NPY5R influences several important functions related to energy balance and feeding behavior. It is part of the NPY receptor family and works by activating intracellular signaling pathways that affect appetite regulation and energy homeostasis. The receptor's activity can modulate food intake making it an important player in energy metabolism. It does not form part of a protein complex but interacts directly with ligands such as NPY and PYY.

Pathways

NPY5R participates in the neuropeptide signaling pathway and the G-protein-coupled receptor pathway. These pathways significantly impact the regulation of hunger and satiety signals. NPY5R closely interacts with other neuropeptide Y receptors such as NPY1R and NPY2R which together create a network that regulates feeding behavior and body weight. These interactions amplify the receptor's role in the central control of energy balance.

NPY5R has a connection to obesity and metabolic syndromes due to its involvement in appetite and energy regulation. Its dysregulation is linked to increased food intake and weight gain. Additionally the receptor has associations with conditions such as anxiety where altered NPY signaling may impact stress responses. NPY and its receptors including NPY5R also relate to other receptors like NPY2R in the modulation of emotional states and metabolic diseases making it a potential target for therapeutic interventions in these conditions.
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Specifications

Form

Liquid

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General info

Function

Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Product protocols

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Target data

Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
See full target information NPY5R
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Complementary Products

Primary Antibodies

AB133757

Anti-NPY5R antibody [EPR8382]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-NPY5R antibody [EPR8382] (AB133757)

  • 5
  • 2

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