Recombinant Human NR2F2 protein is a Human Full Length protein, in the 1 to 414 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M A M V V S T W R D P Q D E V P G S Q G S Q A S Q A P P V P G P P P G A P H T P Q T P G Q G G P A S T P A Q T A A G G Q G G P G G P G S D K Q Q Q Q Q H I E C V V C G D K S S G K H Y G Q F T C E G C K S F F K R S V R R N L S Y T C R A N R N C P I D Q H H R N Q C Q Y C R L K K C L K V G M R R E A V Q R G R M P P T Q P T H G Q F A L T N G D P L N C H S Y L S G Y I S L L L R A E P Y P T S R F G S Q C M Q P N N I M G I E N I C E L A A R M L F S A V E W A R N I P F F P D L Q I T D Q V A L L R L T W S E L F V L N A A Q C S M P L H V A P L L A A A G L H A S P M S A D R V V A F M D H I R I F Q E Q V E K L K A L H V D S A E Y S C L K A I V L F T S D A C G L S D V A H V E S L Q E K S Q C A L E E Y V R S Q Y P N Q P T R F G K L L L R L P S L R T V S S S V I E Q L F F V R L V G K T P I E T L I R D M L L S G S S F N W P Y M A I Q
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development (PubMed:29478779).
Alternative names
ARP1, TFCOUP2, NR2F2, COUP transcription factor 2, COUP-TF2, Apolipoprotein A-I regulatory protein 1, COUP transcription factor II, Nuclear receptor subfamily 2 group F member 2, ARP-1, COUP-TF II
Recommended products
Recombinant Human NR2F2 protein is a Human Full Length protein, in the 1 to 414 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- P24468-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M A M V V S T W R D P Q D E V P G S Q G S Q A S Q A P P V P G P P P G A P H T P Q T P G Q G G P A S T P A Q T A A G G Q G G P G G P G S D K Q Q Q Q Q H I E C V V C G D K S S G K H Y G Q F T C E G C K S F F K R S V R R N L S Y T C R A N R N C P I D Q H H R N Q C Q Y C R L K K C L K V G M R R E A V Q R G R M P P T Q P T H G Q F A L T N G D P L N C H S Y L S G Y I S L L L R A E P Y P T S R F G S Q C M Q P N N I M G I E N I C E L A A R M L F S A V E W A R N I P F F P D L Q I T D Q V A L L R L T W S E L F V L N A A Q C S M P L H V A P L L A A A G L H A S P M S A D R V V A F M D H I R I F Q E Q V E K L K A L H V D S A E Y S C L K A I V L F T S D A C G L S D V A H V E S L Q E K S Q C A L E E Y V R S Q Y P N Q P T R F G K L L L R L P S L R T V S S S V I E Q L F F V R L V G K T P I E T L I R D M L L S G S S F N W P Y M A I Q
- Accession
- P24468
- Protein length
- Full Length
- Amino acids
- 1 to 414
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development (PubMed:29478779).
- Sequence similarities
Belongs to the nuclear hormone receptor family. NR2 subfamily.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
NR2F2 also known as COUP-TFII (Chicken Ovalbumin Upstream Promoter Transcription Factor II) is a nuclear receptor that functions as a transcription factor. It has a molecular mass of approximately 48 kDa. It binds to DNA target sequences and regulates gene expression involved in various developmental processes. NR2F2 is expressed in the heart blood vessels and various tissues such as the lungs and the central nervous system. Its role in transcriptional regulation makes it important for proper cell and tissue differentiation.
- Biological function summary
NR2F2 is involved in the regulation of angiogenesis and cardiovascular development. It forms a heterodimer with retinoid X receptor (RXR) to regulate gene expression. This interaction places NR2F2 as part of a larger network controlling organ development and metabolic processes. NR2F2 activity also influences energy homeostasis and adipogenesis through its transcriptional regulation abilities.
- Pathways
NR2F2 influences the Wnt signaling and Notch signaling pathways which play important roles in cell proliferation and differentiation. These pathways interact with other proteins such as beta-catenin and Notch receptors. NR2F2 modulates gene expression at different cellular stages and contributes to the precise regulation required within these pathways.
- Associated diseases and disorders
NR2F2 is linked to congenital heart defects and cancer. Aberrant NR2F2 expression disrupts normal developmental processes contributing to heart malformations. In cancer altered NR2F2 expression and function can facilitate tumor progression and metastasis often involving interaction with other proteins like TGF-beta and SMADs essential for tumor suppression pathways. The ability of NR2F2 to control critical transcriptional networks makes it a significant target for understanding and potentially treating these conditions.
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1 product image
SDS-PAGE - Recombinant Human NR2F2 protein (ab159680)
ab159680 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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