Recombinant Human NRG1 type II protein (Fc Chimera)
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Recombinant Human NRG1 type II protein (Fc Chimera) is a Human Fragment protein, in the 2 to 246 aa range, expressed in HEK 293 cells, with >88%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
GGF, HGL, HRGA, NDF, SMDF, NRG1, Pro-NRG1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human NRG1 type II protein (Fc Chimera) (AB276410)
SDS-PAGE analysis of ab276410
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
This protein is essential for processes like cell growth differentiation and survival. NRG1 type II is often involved in the formation of multiprotein signaling complexes specifically with ErbB3 and ErbB4 receptors. This interaction can initiate cellular responses critical for the proper functioning of the nervous system and cardiac tissue development. These functions underline the importance of NRG1 type II in maintaining the normal physiological state of these tissues.
Pathways
You find NRG1 type II involved in significant signaling pathways such as the PI3K/AKT and MAPK/ERK pathways. These pathways are essential for regulating cell proliferation and survival. In these signaling cascades NRG1 type II interacts primarily with the ErbB receptor family including proteins such as ErbB2 and ErbB4 forming heterodimers that activate downstream signaling processes essential for cellular health and function.
Specifications
Form
Lyophilized
General info
Function
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed : 10867024, PubMed : 7902537). Binds to ERBB3 (PubMed : 20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV : ITGB3 or ITGA6 : ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed : 20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).
Sequence similarities
Belongs to the neuregulin family.
Post-translational modifications
Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.. N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage (By similarity).
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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