Recombinant Human NRG4 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neuregulin 4 (NRG4) is a member of the neuregulin family. It functions as a signaling molecule with a role in cell communication. NRG4 weighs approximately 40 kDa and mainly expresses in adipose tissue and the brain. It binds to erythroblastic leukemia viral oncogene homolog (ErbB) family receptors especially ErbB4 to execute its functions. These bindings initiate a cascade of intracellular events impacting various cellular activities.

Biological function summary

The protein NRG4 plays a significant role in regulating energy metabolism and maintaining homeostasis. It is not part of a complex but as a ligand it interacts directly with its receptor ErbB4. NRG4 activity helps regulate liver lipid metabolism preventing excessive lipid accumulation. Furthermore NRG4 involvement extends to pancreatic function where it aids in preserving insulin sensitivity with implications for glucose homeostasis.

Pathways

The protein NRG4 acts within the ErbB signaling pathway which is critical for cellular growth and differentiation. In this pathway NRG4 enhances the proliferation and differentiation of cells by activating the ErbB4 receptor. NRG4 also interfaces with the PI3K/AKT pathway playing a role in metabolic processes and cellular survival. The interaction with ErbB4 signifies its relation to other neuregulin proteins like NRG1 which also engage this receptor family showcasing their coordinated impact on metabolic regulation.

The protein NRG4 has links to metabolic disorders such as obesity and type 2 diabetes. Lower levels of NRG4 correlate with increased risk of these conditions highlighting its importance in metabolic health. NRG4 also interacts with inflammatory cytokines in the context of obesity where an imbalance can exacerbate metabolic dysregulation. Additionally in type 2 diabetes the target's association with insulin sensitivity indicates a therapeutic potential alongside its interactive partner ErbB4.