Recombinant Human NRN1L protein (Fc Chimera)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NRN1L also known as Neuritin 1 Like is a protein that has a mass approximately of 28 kDa. It participates in neural signaling processes. You can find NRN1L expressed primarily in the central nervous system especially in the brain. This protein has a role in regulating neurite outgrowth and remodeling acting as an important mediator in neural tissue development through its ability to influence the structural configuration of neurons.

Biological function summary

NRN1L exerts significant effects on neuronal cells where it plays a role in synaptic plasticity and regeneration of nerves. It functions independently rather than being part of a larger protein complex. NRN1L aids in the growth of dendrites and axons which are essential for proper neural communication and network formation. Its modulation of neurogenesis makes it a notable protein in understanding neural development and potential regeneration.

Pathways

NRN1L engages in the neurotrophin signaling and MAPK pathways influencing nearby molecules and proteins such as BDNF and TrkB. These pathways are important in regulating cellular responses tied to growth and differentiation in neural contexts. Interaction with proteins in these pathways highlights the importance of NRN1L in maintaining neural structural integrity and function.

NRN1L shows relevance to neurodegenerative diseases like Alzheimer's and conditions involving neural damage such as stroke. Altered expression of NRN1L could impact its interactions with proteins like APP which associates with Alzheimer's disease pathology. Understanding NRN1L's role in these diseases offers insights into potential therapeutic approaches targeting neural regeneration and protection.