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AB172827

Recombinant Human NST protein

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Recombinant Human NST protein is a Human Full Length protein, in the 1 to 284 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

SULTX3, SULT4A1, Sulfotransferase 4A1, ST4A1, Brain sulfotransferase-like protein, Nervous system sulfotransferase, hBR-STL, hBR-STL-1, NST

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

Tag free

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

Q9BR01

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Previously labelled as SULT4A1.
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Sequence info

[{"sequence":"MAESEAETPSTPGEFESKYFEFHGVRLPPFCRGKMEEIANFPVRPSDVWIVTYPKSGTSLLQEVVYLVSQGADPDEIGLMNIDEQLPVLEYPQPGLDIIKELTSPRLIKSHLPYRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDSNVLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLEALTEHCHQLVDQCCSAEALPVGRGRVGLWKDIFTVSMNEKFDLVYKQKMGKCDLTFDFYL","proteinLength":"Full Length","predictedMolecularWeight":"33 kDa","actualMolecularWeight":null,"aminoAcidEnd":284,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BR01","tags":[]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The NST protein also known popularly as Non-Structural Protein plays an important role in molecular mechanics. It often displays a specific mass which varies depending on its subtype and source within different organisms. NST typically expresses itself in various cell types mainly in those undergoing specific physiological processes or viral replication. Its expression allows it to interact and modulate several cellular activities adapting according to cellular needs and environmental conditions.
Biological function summary

NST proteins perform functions that are integral to cellular operations and survival. As components of several complexes they contribute to the modulation of viral replication processes and cellular stress response mechanisms. Within the host cell NST assists in altering cellular machinery to favor viral propagation ensuring efficiency and survival of viral particles. This modulation often includes interference with normal cell signaling pathways giving malignant cells or viruses a survival advantage.

Pathways

NST proteins interact dynamically with numerous cellular pathways to ensure their effectiveness. They are notably involved in pathways like the viral infection pathway and the stress response pathway. Within these pathways NST proteins often connect with other proteins like polymerases and helicases facilitating the smooth progression of tasks essential for pathogenesis. These interactions highlight the central role NST plays in altering host cellular functions to align with pathogenic needs.

NST relates particularly to viral infections and resultant complications. Diseases such as virus-induced fever and some respiratory disorders have shown an association with NST proteins. In these contexts proteins such as polymerases directly complement the function of NST enhancing pathogenic processes. This association highlights the potential of targeting NST proteins in therapeutic approaches aimed at mitigating the impacts of such infections and aiding in disease management.
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Specifications

Form

Liquid

Additional notes

ab172827 is greater than 95%, as determined by SEC-HPLC and reducing SDS-PAGE. It is supplied as an 0.2 µM filtered solution.

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General info

Function

Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.

Sequence similarities

Belongs to the sulfotransferase 1 family.

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Product protocols

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Target data

Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.
See full target information SULT4A1
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