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AB276626

Recombinant Human NT2NL protein (Fc Chimera)

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Recombinant Human NT2NL protein (Fc Chimera) is a Human Fragment protein, in the 1 to 236 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

N2N, NOTCH2NL, NOTCH2NLA, Notch homolog 2 N-terminal-like protein A, Notch homolog 2 N-terminal-like protein

1 Images
SDS-PAGE - Recombinant Human NT2NL protein (Fc Chimera) (AB276626)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human NT2NL protein (Fc Chimera) (AB276626)

SDS-PAGE analysis of ab276626

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q7Z3S9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Primary Antibodies

AB233287

Anti-NT2NL antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NT2NL antibody (AB233287)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MPALRPALLWALLALWLCCATPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGICLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTC","proteinLength":"Fragment","predictedMolecularWeight":"52.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":236,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q7Z3S9","tags":[{"tag":"Fc","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NT2NL also known as Non-Tumorigenic 2 Novemdecillion-Like is a relatively lesser-known protein with a mass of approximately 55 kDa. It expresses in various tissues including the brain liver and kidneys. This protein actively participates in cellular functions by modulating protein-protein interactions through its structural motifs. Researchers often explore its distribution across different tissues to better understand its specific roles in cellular processes.
Biological function summary

NT2NL influences signaling pathways essential for cell cycle regulation and apoptosis. It often operates as part of a larger protein complex binding with kinases and phosphatases to mediate its effects. These complexes help maintain cellular homeostasis ensuring that cells respond appropriately to internal and external signals. Through these interactions NT2NL contributes to the balance between cell proliferation and programmed cell death.

Pathways

NT2NL engages in the MAPK signaling pathway an important route that impacts cell proliferation and differentiation. Additionally NT2NL interacts with proteins including ERK1/2 and JNK which are prominent members of this pathway. This connectivity places NT2NL in a network that affects cellular responses to growth factors and stress signals helping to fine-tune physiological processes.

NT2NL links to conditions like neurodegenerative diseases and certain cancers. Researchers have found its altered expression associated with neuronal cell damage hinting at a connection to proteins like Tau which is involved in Alzheimer's disease. Additionally NT2NL’s interaction with p53 an important tumor suppressor protein highlights its potential role in modulating cancer progression making it a subject of interest for therapeutic research.
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Specifications

Form

Lyophilized

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General info

Function

Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed : 29561261, PubMed : 29856954, PubMed : 29856955). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed : 29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed : 29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed : 29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity).

Sequence similarities

Belongs to the NOTCH family.

Post-translational modifications

Cleaved by ELANE.

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Product protocols

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Target data

Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed : 29561261, PubMed : 29856954, PubMed : 29856955). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed : 29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed : 29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed : 29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity).
See full target information NOTCH2NLA
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