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AB241514

Recombinant Human NT5C1A protein (His tag)

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Recombinant Human NT5C1A protein (His tag) is a Human Full Length protein, in the 1 to 368 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE.
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SDS-PAGE - Recombinant Human NT5C1A protein (His tag) (AB241514)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human NT5C1A protein (His tag) (AB241514)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel ab241514.

Key facts

Purity

>90% SDS-PAGE

Expression system

Yeast

Tags

6x His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9BXI3-1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"MEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSRALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSEDVFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTAPAKQAPSAQ","proteinLength":"Full Length","predictedMolecularWeight":"43 kDa","actualMolecularWeight":null,"aminoAcidEnd":368,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Yeast","accessionNumber":"Q9BXI3","tags":[{"tag":"6x His","terminus":"N-Terminus"}]}]
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Properties and storage information

Form
Liquid
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NT5C1A also known as cytosolic 5'-nucleotidase 1A is an enzyme involved in the catabolism of nucleotides. It dephosphorylates nucleoside monophosphates into nucleosides and inorganic phosphate. The molecular mass of NT5C1A is approximately 41 kDa. It is expressed in various tissues with notable presence in muscle tissue and peripheral blood mononuclear cells.
Biological function summary

NT5C1A contributes to the regulation of nucleotide pools in cells impacting DNA and RNA synthesis and degradation processes. It functions independently and does not seem to be a part of a larger complex. Its activity ensures balanced nucleotide levels which is essential for proper cellular function and replication.

Pathways

NT5C1A participates in the purine metabolism pathway by influencing the concentration of nucleosides and nucleotides. It works in coordination with other enzymes such as adenosine deaminase and xanthine oxidase within these metabolic processes. NT5C1A's role is pivotal in maintaining nucleotide homeostasis during cellular proliferation and apoptosis.

NT5C1A has been linked to sporadic inclusion body myositis a muscle disorder characterized by muscle inflammation and weakening. Some studies suggest a connection with autoimmune diseases; however research is still evolving in this area. In these conditions NT5C1A interacts with proteins involved in immune response modulation hinting at its role in disease development.
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Product protocols

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Target data

Catalyzes the hydrolysis of ribonucleotide and deoxyribonucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside (PubMed : 11133996, PubMed : 34814800, PubMed : 7599155, PubMed : 8967393). AMP is the major substrate but can also hydrolyze dCMP and IMP (PubMed : 11133996, PubMed : 34814800, PubMed : 7599155, PubMed : 8967393).
See full target information Cytosolic 5'-nucleotidase 1A

Alternative Names

Cytosolic 5'-nucleotidase 1A, cN1A, 5'-deoxynucleotidase, Cytosolic 5'-nucleotidase IA, cN-I, cN-IA, NT5C1A
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