Recombinant Human NTPDase 8 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NTPDase 8 also known as ectonucleoside triphosphate diphosphohydrolase 8 is an enzyme with a molecular mass of approximately 65 kDa. Its main function is to hydrolyze nucleoside triphosphates and diphosphates to nucleoside monophosphates and inorganic phosphate. This reaction occurs on the extracellular surface where NTPDase 8 is located. The enzyme is expressed in various tissues including the liver and gastrointestinal tract contributing to the regulation of extracellular nucleotide levels.

Biological function summary

The enzyme plays an important role in purinergic signaling by controlling concentrations of ATP and ADP in the extracellular environment. NTPDase 8 is not part of a complex but interacts widely in tissue-specific manners. Its activity influences important physiological processes such as inflammation and thromboregulation. By modulating nucleotide levels it affects the signaling pathways involved in these biological processes having a direct impact on cellular communication and homeostasis.

Pathways

NTPDase 8 features prominently in the purinergic signaling pathway and the adenosine triphosphate (ATP) hydrolysis pathway. It is related to other NTPDase family members like NTPDase 1 and NTPDase 2 through its shared role in these pathways. NTPDase 8's enzymatic actions reduce extracellular ATP levels and correspondingly raise adenosine concentrations influencing signaling and responses within the cell particularly in immune and nervous system pathways.

NTPDase 8 is associated with conditions such as chronic inflammatory diseases and certain liver disorders. Its regulation of ATP and ADP levels can contribute to pathological states if dysregulated. The enzyme's activity relates to other proteins involved in these diseases such as ecto-5'-nucleotidase which together can impact purinergic signaling balance and possibly exacerbate inflammatory responses or hepatic function disruptions.