Recombinant Human Nucleolin protein (His tag)
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(1 Publication)
Recombinant Human Nucleolin protein (His tag) is a Human Fragment protein, in the 2 to 482 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
Nucleolin, Protein C23, NCL
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human Nucleolin protein (His tag) (AB241527)
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of ab241527 could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) Nucleolin.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human Nucleolin protein (His tag) (AB241527)
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of ab241527 could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) Nucleolin.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Nucleolin protein (His tag) (AB241527)
ab241527 analyzed by (Tris-Glycine gel) discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The nucleolin molecular weight protein contributes to regulating cellular processes such as chromatin remodeling rRNA transcription and mRNA stability. Nucleolin often forms complexes with various other proteins and nucleic acids enhancing its functionality within the cell nucleus. Its participation in processes like DNA replication and cell proliferation shows the central role nucleolin plays at the cellular level. It influences cellular responses by binding directly to specific RNA or DNA sequences.
Pathways
The nucleolin protein engages in major cellular pathways such as the RNA processing and p53 signaling pathways. Through the RNA processing pathway it interacts with proteins like fibrillarin to assist in rRNA maturation. Moreover within the p53 signaling pathway nucleolin regulates the activity of the tumor suppressor protein p53 impacting cell cycle progression and apoptosis. These interactions highlight nucleolin's role in maintaining cellular homeostasis and response to stress.
Specifications
Form
Liquid
General info
Function
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
Post-translational modifications
Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).. Symmetrically methylated by PRMT5.
Subcellular localisation
Nucleus
Target data
Publications (1)
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Molecular cell 81:3481-3495.e7 PubMed34358446
2021
Applications
Unspecified application
Species
Unspecified reactive species
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Product promise
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