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AB276635

Recombinant Human NUDC protein (His tag)

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Recombinant Human NUDC protein (His tag) is a Human Full Length protein, in the 1 to 331 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Nuclear migration protein nudC, Nuclear distribution protein C homolog, NUDC

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SDS-PAGE - Recombinant Human NUDC protein (His tag) (AB276635)
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Supplier Data

SDS-PAGE - Recombinant Human NUDC protein (His tag) (AB276635)

SDS-PAGE analysis of ab276635

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9Y266

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 20% Glycerol (glycerin, glycerine), 2.9% Sodium chloride, 0.24% Tris

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGGEQEEERFDGMLLAMAQQHEGGVQELVNTFFSFLRRKTDFFIGGEEGMAEKLITQTFSHHNQLAQKTRREKRARQEAERREKAERAARLAKEAKSETSGPQIKELTDEEAERLQLEIDQKKDAENHEAQLKNGSLDSPGKQDTEEDEEEDEKDKGKLKPNLGNGADLPNYRWTQTLSELDLAVPFCVNFRLKGKDMVVDIQRRHLRVGLKGQPAIIDGELYNEVKVEESSWLIEDGKVVTVHLEKINKMEWWSRLVSSDPEINTKKINPENSKLSDLDSETRSMVEKMMYDQRQKSMGLPTSDEQKKQEILKKFMDQHPEMDFSKAKFN","proteinLength":"Full Length","predictedMolecularWeight":"39.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":331,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9Y266","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NUDC also known as Nuclear Distribution Protein C is a conserved protein with a molecular weight of approximately 38 kDa. It is essential for the proper function of the cell division process. Throughout different stages of the cell cycle NUDC localizes to microtubules and the spindle apparatus. The protein shows a high level of expression in tissues with rapid cell division such as testis bone marrow and embryonic tissues. Its conserved nature points to a critical role in cellular operations across various organisms.
Biological function summary

NUDC plays a significant role in mitotic processes. The protein acts alongside members of the dynein motor complex influencing spindle assembly and chromosome alignment. NUDC's presence in centrosomes and the mitotic spindle highlights its role in maintaining genomic stability during cell division. Ensuring accurate chromosome segregation is one of the key biological responsibilities of this protein as errors in these processes can lead to aneuploidy often related to cancer development.

Pathways

Cellular transport and mitotic progression are two critical systems involving NUDC. It associates closely with the cytoplasmic dynein motor complex and interacts with proteins like LIS1 and NudE which modulate dynein activity. In the spindle assembly checkpoint pathway NUDC works to ensure proper kinetochore-microtubule attachments preventing premature anaphase onset and maintaining cell cycle fidelity. Its coordination within these pathways indicates a foundational role in cell division-related processes.

NUDC has links to neurodevelopmental disorders and cancers. Disruptions in NUDC's function can impact brain development with a correlation observed in cases of lissencephaly where improper neuronal migration is a hallmark. The protein's interaction with LIS1 is noteworthy in this context. Additionally aberrant NUDC expression or mutations play a part in tumorigenesis particularly in leukemias. Research shows that defective NUDC function may result in genomic instability a contributing factor in the progression of certain cancer types.
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Specifications

Form

Lyophilized

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General info

Function

Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed : 12679384, PubMed : 12852857, PubMed : 25789526). Necessary for cytokinesis and cell proliferation (PubMed : 12679384, PubMed : 12852857).

Sequence similarities

Belongs to the nudC family.

Post-translational modifications

Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed : 12679384, PubMed : 12852857, PubMed : 25789526). Necessary for cytokinesis and cell proliferation (PubMed : 12679384, PubMed : 12852857).
See full target information Nuclear migration protein nudC
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