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AB177724

Recombinant Human NUDCD2 protein (His tag N-Terminus)

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Recombinant Human NUDCD2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 157 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

NudC domain-containing protein 2, NUDCD2

1 Images
SDS-PAGE - Recombinant Human NUDCD2 protein (His tag N-Terminus) (AB177724)
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Supplier Data

SDS-PAGE - Recombinant Human NUDCD2 protein (His tag N-Terminus) (AB177724)

15% SDS-PAGE analysis of ab177724 (3μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q8WVJ2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSAPFEERSGVVPCGTPWGQWYQTLEEVFIEVQVPPGTRAQDIQCGLQSRHVALSVGGREILKGKLFDSTIADEGTWTLEDRKMVRIVLTKTKRDAANCWTSLLESEYAADPWVQDQMQRKLTLERFQKENPGFDFSGAEISGNYTKGGPDFSNLEK","proteinLength":"Full Length","predictedMolecularWeight":"20 kDa","actualMolecularWeight":null,"aminoAcidEnd":157,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WVJ2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NUDCD2 also known as NudC Domain Containing 2 is a protein that plays a role in cellular processes like protein transport. This protein weighs approximately 45 kDa. NUDCD2 locates primarily in the cytoplasm where it interacts with microtubules. The expression profile of NUDCD2 shows its presence in multiple tissues including liver lungs and lymph nodes highlighting its significance in these areas.
Biological function summary

The actions of NUDCD2 involve interactions with the mitotic spindle suggesting a role in cell division. NUDCD2 associates with elements of the dynein-dynactin complex which implies participation in intracellular transport mechanisms. This complex facilitates processes essential for efficient mitotic spindle function an important aspect of cell division and proper chromosome segregation.

Pathways

NUDCD2 is involved in the regulation of the microtubule cytoskeleton. It functions within pathways like the cell cycle regulation pathway in particular during mitosis. NUDCD2 is related to proteins such as dynein which contribute to the stabilization of microtubules and proper mitotic spindle formation. This connection indicates that NUDCD2 impacts processes that control cell proliferation and genomic stability.

NUDCD2 has connections to cancer where disruptions in its function could lead to abnormal cell division and tumor formation. Impaired regulation of proteins like NUDCD2 might result in missegregation of chromosomes promoting oncogenesis. Additionally NUDCD2 implications in neurological disorders exist since defects in microtubule-related processes can lead to neurodevelopmental issues linking it with proteins involved in neuronal function and stability.
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Specifications

Form

Liquid

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General info

Function

May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.
See full target information NUDCD2
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