Recombinant Human NUDT10 protein (His tag C-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NUDT10 also known as Nucleoside Diphosphate-Linked Moiety X-Type Motif 10 functions as a hydrolase enzyme. It cleaves nucleotides by hydrolyzing 8-oxo-78-dihydroguanosine diphosphate (8-oxo-dGDP) and monophosphate (8-oxo-dGMP) into less reactive forms. This protein has a mass of approximately 21 kDa. NUDT10 is expressed in several tissues including the liver and lungs suggesting its significance in oxidative stress response and nucleotide metabolism.

Biological function summary

NUDT10 helps maintain nucleotide pool balance and reduces oxidative DNA damage by converting oxidized nucleotide derivatives into non-mutagenic forms. This enzyme might act independently or in coordination with other NUDT family members though not clearly part of a larger complex. By mitigating the accumulation of oxidized nucleotides NUDT10 contributes to genomic stability and cellular homeostasis.

Pathways

NUDT10 plays an important role in both the nucleotide metabolism and oxidative stress response pathways. It closely relates to the activity of other proteins such as NUDT1 which also degrades oxidized nucleotides. Through its enzymatic action NUDT10 ensures proper DNA replication and repair by preventing incorporation of damaged nucleotides into DNA thereby supporting the cell's ability to manage oxidative stress and maintain proper function.

Mutations or altered expression of NUDT10 may relate to cancer development and neurodegenerative diseases like Alzheimer's. In cancer its role in managing oxidative stress connects it to proteins like p53 which regulates cell cycle and apoptosis. Abnormal NUDT10 activity could lead to increased mutagenesis contributing to disease progression. Understanding its function in these pathways highlights its importance as a target for therapeutic intervention in oxidative stress-related conditions.