Recombinant Human NUDT2 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein NUDT2 also known as Nucleoside Diphosphate-Linked Moiety X-Type Motif 2 is an enzyme that hydrolyzes nucleoside diphosphates. It has a molecular mass of approximately 22 kDa. This protein is expressed in various tissues including the brain liver and heart. NUDT2's mechanical function centers on its ability to regulate cellular nucleoside diphosphate levels by converting them into their monophosphate forms which is vital for the proper recycling of nucleotide pool components.

Biological function summary

The protein plays a role in controlling intracellular hydrolysis of nucleoside diphosphates ensuring proper nucleotide balance. Although it operates independently it functions in synergy with other proteins involved in nucleotide metabolism. This precision in nucleotide regulation is essential for maintaining nucleic acid synthesis as well as energy transfer processes within the cell. NUDT2 does not form large complexes but interacts dynamically within metabolic hubs.

Pathways

NUDT2 participates in nucleotide metabolism and salvage pathways. It contributes predominantly to pathways that recycle nucleotides essential for cellular replication and repair processes. Within these pathways NUDT2 closely interacts with enzymes such as nucleoside diphosphate kinases which play a complementary role in maintaining nucleotide balance. These interactions ensure efficient utilization of resources required for vital cellular functions.

NUDT2 has been linked to conditions such as cancer and metabolic disorders. Aberrant expression or dysfunction of NUDT2 can result in nucleotide imbalance leading to problems with cell proliferation or metabolic dysregulation. In certain cancers altered expression of NUDT2 in conjunction with disrupted functions of tumor suppressor proteins can contribute to uncontrolled cell growth. Understanding NUDT2's role in these diseases can guide therapeutic strategies aimed at restoring normal nucleotide metabolism.