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AB107153

Recombinant Human NUDT9 protein

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Recombinant Human NUDT9 protein is a Human Full Length protein, in the 47 to 350 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

NUDT10, PSEC0099, UNQ3012/PRO9771, NUDT9, ADP-ribose diphosphatase, ADP-ribose phosphohydrolase, Adenosine diphosphoribose pyrophosphatase, Nucleoside diphosphate-linked moiety X motif 9, ADPR-PPase, Nudix motif 9

1 Images
SDS-PAGE - Recombinant Human NUDT9 protein (AB107153)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human NUDT9 protein (AB107153)

15% SDS-PAGE showing ab107153 (3μg).
Note : Molecular weight on SDS-PAGE will appear higher.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9BW91

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMNTNVMSGSNGSKENSHNKARTSPYPGSKVERSQVPNEKVGWLVEWQDYKPVEYTAVSVLAGPRWADPQISESNFSPKFNEKDGHVERKSKNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPIITRWKRDSSGNKIMHPVSGKHILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEEALNSLQKTSAEKREIEEKLHKLFSQDHLVIYKGYVDDPRNTDNAWMETEAVNYHDETGEIMDNLMLEAGDDAGKVKWVDINDKLKLYASHSQFIKLVAEKRDAHWSEDSEADCHAL","proteinLength":"Full Length","predictedMolecularWeight":"36.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":350,"aminoAcidStart":47,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BW91","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NUDT9 also known as Nudix Hydrolase 9 is an enzyme that exhibits pyrophosphatase activity on molecules like ADP-ribose. It has an approximate mass of 35 kDa. NUDT9 is expressed in various tissues with significant levels observed in the brain and heart. This protein helps break down ADP-ribose into AMP and ribose-5-phosphate assisting in the regulation of cellular ADP-ribose concentrations.
Biological function summary

NUDT9 helps to maintain cellular balance by controlling levels of ADP-ribose a substrate for poly ADP-ribose polymerases. This regulation is essential for energy metabolism and DNA repair processes. NUDT9 operates independently and does not blend into larger protein complexes focusing strictly on its enzymatic role ensuring the cell's homeostasis.

Pathways

NUDT9 is significantly involved in NAD+ metabolism and the DNA repair mechanism. By converting ADP-ribose NUDT9 interacts with pathways that are central to maintaining cellular energy balance and protecting cells from DNA damage. It is functionally linked with enzymes such as PARP (poly ADP-ribose polymerase) which are pivotal in detecting and signaling DNA strand breaks.

NUDT9's role in regulating ADP-ribose links it to conditions where cellular stress and energy metabolism are disrupted. Its malfunction has correlations with neurodegenerative diseases like Alzheimer's where altered energy metabolism and DNA damage responses are critical factors. NUDT9 also connects with proteins like PARP which are implicated in this pathological context indicating a potential therapeutic target for managing such disorders.
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Specifications

Form

Liquid

Additional notes

ab107153 is purified using conventional chromatography techniques.

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General info

Function

Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.

Sequence similarities

Belongs to the Nudix hydrolase family. NudF subfamily.

Subcellular localisation

Mitochondrion

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Product protocols

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Target data

Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
See full target information NUDT9
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Complementary Products

Proteins & Peptides

AB103059

Recombinant Human NUDT16 protein

SDS-PAGE - Recombinant Human NUDT16 protein (AB103059)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
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Primary Antibodies

AB197021

Anti-NUDT9 antibody [EPR15175]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-NUDT9 antibody [EPR15175] (AB197021)

  • 0
  • 0
Secondary Antibodies

AB150191

Rabbit Anti-Human IgM mu chain (Alexa Fluor® 647)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Rabbit Anti-Human IgM mu chain (Alexa Fluor® 647) (AB150191)

  • 0
  • 0

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