Recombinant Human NUP62CL protein (denatured) (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NUP62CL also known as Nucleoporin 62 C-terminal-like is an important component of the nuclear pore complex (NPC). It weighs approximately 56 kDa. This protein is expressed in various tissues with higher levels observed in the brain liver and kidneys. Its primary mechanical role involves the transport of molecules across the nuclear envelope making it a critical player in nucleocytoplasmic transport.

Biological function summary

NUP62CL contributes to the integrity of the nuclear pore complex by participating in the assembly and disassembly of NPCs. It interacts with other nucleoporins as part of the complex structure. NUP62CL ensures effective bidirectional transport of proteins and RNA impacting cell signaling and cycle control. Its function is essential for maintaining normal cellular activities and any disruption can lead to cellular dysfunction.

Pathways

NUP62CL is a component of the nuclear transport pathway which is important for the regulation of gene expression. It interacts with other nucleoporins such as NUP98 and NUP96 facilitating the transport of transcriptional regulators and mRNA molecules. NUP62CL is also involved in the Ran GTPase cycle a pathway important for mitotic spindle assembly and subsequent cell division processes. These interactions highlight its role in cellular regulation.

Altered NUP62CL expression or function links to neurodegenerative diseases and cancer. Disruption in nucleocytoplasmic transport can result in accumulation of misfolded proteins associated with Alzheimer's disease pathogenesis. Moreover the abnormal function of NUP62CL may contribute to cancer through its interaction with oncogenic proteins like p53 influencing the maintenance of genomic stability. Its association with these conditions highlights the importance of NUP62CL in disease development.