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AB222981

Recombinant Human NXPH1 protein (His tag)

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Recombinant Human NXPH1 protein (His tag) is a Human Full Length protein, in the 22 to 271 aa range, expressed in Baculovirus infected insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

NPH1, Nbla00697, NXPH1, Neurexophilin-1

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SDS-PAGE - Recombinant Human NXPH1 protein (His tag) (AB222981)
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Supplier Data

SDS-PAGE - Recombinant Human NXPH1 protein (His tag) (AB222981)

15% SDS-PAGE analysis of 3 μg ab222981.

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Baculovirus infected insect cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P58417

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"ADPANLTNGGKSELLKSGSSKSTLKHIWTESSKDLSISRLLSQTFRGKENDTDLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRPRAKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQGNVSVSLVPPTKIVEFDLAQQTVIDAKDSKSFNCRIEYEKVDKATKNTLCNYDPSKTCYQEQTQSHVSWLCSKPFKVICIYISFYSTDYKLVQKVCPDYNYHSDTPYFPSGHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"29.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":271,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"P58417","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NXPH1 or Neurexophilin-1 is a protein involved in synaptic function. This protein weighs approximately 32 kDa and plays a role in neurotransmitter release. Researchers recognize NXPH1 by its presence in the central nervous system notably expressed in the brain. NXPH1 acts as a ligand for neurexins which are essential for synapse formation and function.
Biological function summary

Neurexophilin-1 participates in neuronal communication and acts as part of a complex with neurexins. By binding to neurexins NXPH1 influences the organization of synaptic junctions facilitating signaling between neurons. These interactions are critical for processes such as learning and memory as they support the maintenance and regulation of synaptic connections.

Pathways

NXPH1 significantly contributes to the regulation of neurotransmission and synaptic signaling. In the glutamatergic synaptic pathway NXPH1 interacts with neurexins to facilitate the release of glutamate an important neurotransmitter. Additionally it may play a role in the dopaminergic synaptic pathways by influencing dopamine receptor connectivity with proteins like neuroligins.

Neurexophilin-1 has connections to neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. In these conditions alterations in NXPH1 expression or function may disrupt synaptic organization leading to impaired neuronal communication. The interaction between NXPH1 and neurexins such as NRXN1 becomes important in understanding the synaptic abnormalities observed in these disorders.
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Specifications

Form

Liquid

Additional notes

Affinity purified

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General info

Function

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

Sequence similarities

Belongs to the neurexophilin family.

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Product protocols

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Target data

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
See full target information NXPH1
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