Recombinant Human NXPH1 protein (His tag) is a Human Full Length protein, in the 22 to 271 aa range, expressed in Baculovirus infected insect, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- Baculovirus infected insect cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
A D P A N L T N G G K S E L L K S G S S K S T L K H I W T E S S K D L S I S R L L S Q T F R G K E N D T D L D L R Y D T P E P Y S E Q D L W D W L R N S T D L Q E P R P R A K R R P I V K T G K F K K M F G W G D F H S N I K T V K L N L L I T G K I V D H G N G T F S V Y F R H N S T G Q G N V S V S L V P P T K I V E F D L A Q Q T V I D A K D S K S F N C R I E Y E K V D K A T K N T L C N Y D P S K T C Y Q E Q T Q S H V S W L C S K P F K V I C I Y I S F Y S T D Y K L V Q K V C P D Y N Y H S D T P Y F P S G H H H H H H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
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Target data
Function
May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
Alternative names
NPH1, Nbla00697, NXPH1, Neurexophilin-1
Recommended products
Recombinant Human NXPH1 protein (His tag) is a Human Full Length protein, in the 22 to 271 aa range, expressed in Baculovirus infected insect, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- Baculovirus infected insect cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P58417-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: PBS, 10% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
- A D P A N L T N G G K S E L L K S G S S K S T L K H I W T E S S K D L S I S R L L S Q T F R G K E N D T D L D L R Y D T P E P Y S E Q D L W D W L R N S T D L Q E P R P R A K R R P I V K T G K F K K M F G W G D F H S N I K T V K L N L L I T G K I V D H G N G T F S V Y F R H N S T G Q G N V S V S L V P P T K I V E F D L A Q Q T V I D A K D S K S F N C R I E Y E K V D K A T K N T L C N Y D P S K T C Y Q E Q T Q S H V S W L C S K P F K V I C I Y I S F Y S T D Y K L V Q K V C P D Y N Y H S D T P Y F P S G H H H H H H
- Accession
- P58417
- Protein length
- Full Length
- Predicted molecular weight
- 29.7 kDa
- Amino acids
- 22 to 271
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Liquid
- Additional notes
Affinity purified
General info
- Function
May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
- Sequence similarities
Belongs to the neurexophilin family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
NXPH1 or Neurexophilin-1 is a protein involved in synaptic function. This protein weighs approximately 32 kDa and plays a role in neurotransmitter release. Researchers recognize NXPH1 by its presence in the central nervous system notably expressed in the brain. NXPH1 acts as a ligand for neurexins which are essential for synapse formation and function.
- Biological function summary
Neurexophilin-1 participates in neuronal communication and acts as part of a complex with neurexins. By binding to neurexins NXPH1 influences the organization of synaptic junctions facilitating signaling between neurons. These interactions are critical for processes such as learning and memory as they support the maintenance and regulation of synaptic connections.
- Pathways
NXPH1 significantly contributes to the regulation of neurotransmission and synaptic signaling. In the glutamatergic synaptic pathway NXPH1 interacts with neurexins to facilitate the release of glutamate an important neurotransmitter. Additionally it may play a role in the dopaminergic synaptic pathways by influencing dopamine receptor connectivity with proteins like neuroligins.
- Associated diseases and disorders
Neurexophilin-1 has connections to neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. In these conditions alterations in NXPH1 expression or function may disrupt synaptic organization leading to impaired neuronal communication. The interaction between NXPH1 and neurexins such as NRXN1 becomes important in understanding the synaptic abnormalities observed in these disorders.
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1 product image
SDS-PAGE - Recombinant Human NXPH1 protein (His tag) (ab222981)
15% SDS-PAGE analysis of 3 μg ab222981.
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