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AB123209

Recombinant Human NXT2 protein (His tag N-Terminus)

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Recombinant Human NXT2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 197 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

BM-025, DC9, NXT2, NTF2-related export protein 2, Protein p15-2

1 Images
SDS-PAGE - Recombinant Human NXT2 protein (His tag N-Terminus) (AB123209)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human NXT2 protein (His tag N-Terminus) (AB123209)

15% SDS-PAGE analysis of ab123209 (3μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9NPJ8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 40% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMRKYRSHWSQGDREGYQRRSNYYEGPHTSHSSPADRTREEVVTPTLPEHTATRSQMATSLDFKTYVDQACRAAEEFVNIYYETMDKRRRALTRLYLDKATLIWNGNAVSGLDALNNFFDTLPSSEFQVNMLDCQPVHEQATQSQTTVLVVTSGTVKFDGNKQHFFNQNFLLTAQSTPNNTVWKIASDCFRFQDWSSS","proteinLength":"Full Length","predictedMolecularWeight":"25.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":197,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NPJ8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NXT2 also known as NTF2-like export factor 2 plays a role in nuclear transport. This protein has a molecular mass of approximately 14 kDa. It is expressed in a variety of tissues primarily in the nucleus where it functions in the export of RNA from the nucleus to the cytoplasm. The protein's mechanical action facilitates the translocation of mRNA and tRNA substrates across the nuclear envelope an essential step in gene expression regulation.
Biological function summary

NXT2 is involved in the transport machinery where it associates with nuclear export complexes. It interacts with other proteins like NXF1 to function as a part of the mRNA export pathway. The presence of NXT2 in these export complexes highlights its necessity in post-transcriptional regulation. This role emphasizes its significance in maintaining cellular function by ensuring that mRNA is correctly moved to the cytoplasm for translation.

Pathways

NXT2 has essential roles in the mRNA nuclear export pathway and is also linked to the tRNA export pathway. These pathways are important for proper gene expression and protein synthesis. NXT2 interacts closely with proteins such as NXF1 and other nucleoporins acting as an important component in these pathways. Its role in these processes hints at its broader implications in cellular signaling and adaptation directly influencing how cells respond to environmental and developmental cues.

Alterations in NXT2 function can relate to cancer and neurodegenerative disorders. Abnormal NXT2 activity may disrupt RNA export leading to uncontrolled cell growth or impaired neuronal function. NXT2's relationship with proteins involved in these diseases such as NXF1 in the case of cancer highlights its importance in disease pathology. These connections point to NXT2 as a potential target for therapeutic intervention opening avenues for more precise treatment strategies.
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Specifications

Form

Liquid

Additional notes

ab123209 is purified using conventional chromatography techniques.

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General info

Function

Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.
See full target information NXT2
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Complementary Products

Primary Antibodies

AB121797

Anti-NXT2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NXT2 antibody (AB121797)

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