Recombinant Human NY-BR-1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NY-BR-1 also known as Lactation Elevated Membrane Protein (LAMP) or New York Breast Cancer 1 is a protein with a molecular mass of approximately 66 kDa. This protein is expressed mainly in breast tissue especially in lactating mammary glands and shows restricted expression outside of reproductive tissues. Its expression pattern suggests a role in cellular activities specific to these tissues. NY-BR-1 is also detectable in certain breast cancer cell lines indicating its potential involvement in oncogenic processes within breast tissue.

Biological function summary

NY-BR-1 plays a significant role in cellular proliferation and differentiation contributing to the regulation of mammary gland development and function. It is not part of any known larger protein complexes operating independently to exert its effects on cell function. The expression pattern suggests its involvement in ensuring proper function of lactating mammary glands where cell specialization is important to support milk production in mammals.

Pathways

NY-BR-1's biological function integrates into the framework of the lactation and mammary gland development pathways. It interfaces with the estrogen signaling pathway which involves proteins like estrogen receptors important for breast tissue development and function. The regulation of mammary gland function by estrogen indicates that NY-BR-1 might act in concert with these receptors to mediate its effects in breast tissue.

NY-BR-1 has strong connections with breast cancer. Its aberrant expression in malignant breast tissues suggests a role in the disease's progression possibly through interaction pathways involving oncogenes and tumor suppressors like BRCA1. The specific expression in certain breast cancer subtypes makes it a candidate as a biomarker for diagnosis or a target for therapeutic intervention aiding in the understanding and treatment of this prevalent cancer type.