Recombinant Human NY-BR-1 protein is a Human Fragment protein, in the 948 to 1055 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
S E A K E I K S Q L E N Q K V K W E Q E L C S V R L T L N Q E E E K R R N A D I L N E K I R E E L G R I E E Q H R K E L E V K Q Q L E Q A L R I Q D I E L K S V E S N L N Q V S H T H E N E N Y L L H E N C M L K K E I
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Alternative names
Ankyrin repeat domain-containing protein 30A, Serologically defined breast cancer antigen NY-BR-1, ANKRD30A
Recommended products
Recombinant Human NY-BR-1 protein is a Human Fragment protein, in the 948 to 1055 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q9BXX3-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- S E A K E I K S Q L E N Q K V K W E Q E L C S V R L T L N Q E E E K R R N A D I L N E K I R E E L G R I E E Q H R K E L E V K Q Q L E Q A L R I Q D I E L K S V E S N L N Q V S H T H E N E N Y L L H E N C M L K K E I
- Accession
- Q9BXX3
- Protein length
- Fragment
- Amino acids
- 948 to 1055
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
NY-BR-1 also known as Lactation Elevated Membrane Protein (LAMP) or New York Breast Cancer 1 is a protein with a molecular mass of approximately 66 kDa. This protein is expressed mainly in breast tissue especially in lactating mammary glands and shows restricted expression outside of reproductive tissues. Its expression pattern suggests a role in cellular activities specific to these tissues. NY-BR-1 is also detectable in certain breast cancer cell lines indicating its potential involvement in oncogenic processes within breast tissue.
- Biological function summary
NY-BR-1 plays a significant role in cellular proliferation and differentiation contributing to the regulation of mammary gland development and function. It is not part of any known larger protein complexes operating independently to exert its effects on cell function. The expression pattern suggests its involvement in ensuring proper function of lactating mammary glands where cell specialization is important to support milk production in mammals.
- Pathways
NY-BR-1's biological function integrates into the framework of the lactation and mammary gland development pathways. It interfaces with the estrogen signaling pathway which involves proteins like estrogen receptors important for breast tissue development and function. The regulation of mammary gland function by estrogen indicates that NY-BR-1 might act in concert with these receptors to mediate its effects in breast tissue.
- Associated diseases and disorders
NY-BR-1 has strong connections with breast cancer. Its aberrant expression in malignant breast tissues suggests a role in the disease's progression possibly through interaction pathways involving oncogenes and tumor suppressors like BRCA1. The specific expression in certain breast cancer subtypes makes it a candidate as a biomarker for diagnosis or a target for therapeutic intervention aiding in the understanding and treatment of this prevalent cancer type.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human NY-BR-1 protein (ab164840)
ab164840 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com