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AB132656

Recombinant Human OAS2 protein

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Recombinant Human OAS2 protein is a Human Full Length protein, in the 1 to 687 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

2'-5'-oligoadenylate synthase 2, (2-5')oligo(A) synthase 2, 2-5A synthase 2, p69 OAS / p71 OAS, p69OAS / p71OAS, OAS2

1 Images
SDS-PAGE - Recombinant Human OAS2 protein (AB132656)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human OAS2 protein (AB132656)

12.5% SDS-PAGE analysis of ab132656 stained with Coomassie Blue

Key facts

Expression system

Wheat germ

Tags

Tag free

Applications

WB, SDS-PAGE, ELISA

applications

Biologically active

No

Accession

P29728

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGNGESQLSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEPEQFPLVQGVAIGGSYGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKWLKNNFEIQKSLDGFTIQVFTKNQRISFEVLAAFNALSLNDNPSPWIYRELKRSLDKTNASPGEFAVCFTELQQKFFDNRPGKLKDLILLIKHWHQQCQKKIKDLPSLSPYALELLTVYAWEQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQSARPVILDPVDPTNNVSGDKICWQWLKKEAQTWLTSPNLDNELPAPSWNVLPAPLFTTPGHLLDKFIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAKIQIVRGGSTAKGTALKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKAPRVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLPGGEFSTCFTVLQRNFIRSRPTKLKDLIRLVKHWYKECERKLKPKGSLPPKYALELLTIYAWEQGSGVPDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEPTGDVGGGDRWCWHLLAKEAKEWLSSPCFKDGTGNPIPPWKVPVKVI","proteinLength":"Full Length","predictedMolecularWeight":"105.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":687,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P29728","tags":[]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Oligoadenylate synthetase 2 (OAS2) is also known as OAS2A and OAS2LLC. It belongs to the 2'-5' oligoadenylate synthase family and possesses a mass of approximately 71 kDa. OAS2 is expressed in various tissues with higher levels noted in the liver and immune cells. Its mechanical function involves the synthesis of 2'-5' linked oligoadenylates (2-5A) upon activation by double-stranded RNA a byproduct of viral infections signalling for the degradation of viral RNA.
Biological function summary

OAS2 is essential in the innate immune response against viral infections. It forms part of a protein complex that activates RNase L an enzyme responsible for degrading viral and cellular RNA thereby limiting viral replication. By doing this OAS2 helps control viral proliferation during the early phases of infection contributing to the host's antiviral defense mechanisms.

Pathways

OAS2 functions in the antiviral pathway related to the innate immune response. It closely associates with the interferon signaling pathway initiating a cascade of reactions that enhance the immune response. RNase L and OAS1 are important proteins related to OAS2 in this pathway. Both proteins synergistically work to recognize and respond to viral infections ensuring an effective and timely immune response.

Researchers have linked OAS2 to diseases such as viral hepatitis and autoimmune disorders like SLE (Systemic Lupus Erythematosus). In viral hepatitis OAS2 plays a role in limiting the replication of hepatitis viruses and studies have observed its interaction with proteins like interleukin-6 (IL-6) within the context of SLE. The aberrant activation or regulation of OAS2 might contribute to disease pathogenesis or severity making it a potential target for therapeutic intervention.
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Specifications

Form

Liquid

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General info

Function

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed : 10464285, PubMed : 9880569). Activated by detection of double stranded RNA (dsRNA) : polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed : 10464285, PubMed : 11682059, PubMed : 9880569). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed : 10464285, PubMed : 9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed : 21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed : 21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity).

Sequence similarities

Belongs to the 2-5A synthase family.

Post-translational modifications

Myristoylation is not essential for its activity.. Glycosylated. Glycosylation is essential for its activity.

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Product protocols

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Target data

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed : 10464285, PubMed : 9880569). Activated by detection of double stranded RNA (dsRNA) : polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed : 10464285, PubMed : 11682059, PubMed : 9880569). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed : 10464285, PubMed : 9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed : 21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed : 21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity).
See full target information OAS2
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