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AB276546

Recombinant Human OIF protein (His tag)

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Recombinant Human OIF protein (His tag) is a Human Full Length protein, in the 1 to 298 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

OIF, SLRR3A, OGN, Mimecan, Osteoglycin, Osteoinductive factor

1 Images
SDS-PAGE - Recombinant Human OIF protein (His tag) (AB276546)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human OIF protein (His tag) (AB276546)

SDS-PAGE analysis of ab276546

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P20774

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"MKTLQSTLLLLLLVPLIKPAPPTQQDSRIIYDYGTDNFEESIFSQDYEDKYLDGKNIKEKETVIIPNEKSLQLQKDEAITPLPPKKENDEMPTCLLCVCLSGSVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADIPNLRRLDFTGNLIEDIEDGTFSKLSLLEELSLAENQLLKLPVLPPKLTLFNAKYNKIKSRGIKANAFKKLNNLTFLYLDHNALESVPLNLPESLRVIHLQFNNIASITDDTFCKANDTSYIRDRIEEIRLEGNPIVLGKHPNSFICLKRLPIGSYF","proteinLength":"Full Length","predictedMolecularWeight":"33.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":298,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P20774","tags":[{"tag":"His","terminus":"C-Terminus"}]}]

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OIF also known as Ovulation Inducing Factor has a mass of about 14 kDa. It plays an important role in inducing ovulation in certain mammalian species. OIF is expressed in seminal plasma where it serves as a signaling molecule influencing the reproductive cycle. Researchers recognize the impact of OIF on the ovarian follicle where it initiates a cascade of events that lead to ovulation. Its discovery is significant for reproductive biology as it highlights the influence of male factors on female reproductive physiology.
Biological function summary

Ovulation Inducing Factor acts as a signaling molecule that interacts with the female reproductive system to trigger ovulation. It functions as part of a larger biochemical complex that affects the hypothalamus and pituitary gland axis stimulating the secretion of hormones necessary for the release of the egg. The exact interactions and pathways remain an active area of research but the ability of OIF to prompt ovulation positions it as a unique factor among reproductive proteins.

Pathways

There is evidence that Ovulation Inducing Factor is involved in the neuroendocrine pathway for ovulation. OIF interacts with the hypothalamus-pituitary-gonadal axis to initiate ovulation. The presence of other proteins like GnRH and its release is closely tied to the activity of OIF in stimulating the necessary hormonal environment. Furthermore the interplay between OIF and luteinizing hormone (LH) is also explored showing how these elements integrate into the broader signaling cascade essential for ovulation.

Researchers have associated Ovulation Inducing Factor with fertility issues. Disruptions or alterations in the pathway involving OIF can lead to ovulatory disorders impacting fertility in both females and indirectly males. Studies explore its relationship with proteins like FSH and LH which are critical in ovulatory processes. Understanding the role of OIF may advance treatment options for certain infertility problems offering insights into novel therapeutic strategies.

Specifications

Form

Lyophilized

General info

Function

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

Post-translational modifications

O-glycosylated with a core 1 or possibly core 8 glycan.. Contains keratan sulfate.

Product protocols

Target data

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
See full target information OGN

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