Recombinant Human Olfactory receptor 10X1 protein is a Human Full Length protein, in the 1 to 309 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M K I N Q T I L K E F I L V G F S V Y P H V Q T F L F V V F F C L Y L L T L A G N L I I M G L T W V D R S L H T P M Y L F L S A L S F S E T C Y T L T I V P K M L E D L L A K D R S I S V T G C S L Q M C F F L G L G G T N C I I L T L M G Y D R F L A I C N P L R Y P L L M T N I V C G Q L V A S A C T A G F F I S L T E T A L I F R D S F C R P N L V K H F F C H M L A V I R L S C I D S N H T E F I I T L I S V S G L L G T L L L I I L T D V F I I S T V L R I P S A E G K Q K A F T T C A S H L T V V I I H F G F A S I V Y L K P E A S G D D T L I A V P Y T V I T P F L S P I I F S L R N K D M K N A F R R M M G N T V A L K K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Alternative names
OR10X1P, OR10X1, Olfactory receptor 10X1, Olfactory receptor OR1-14
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Recombinant Human Olfactory receptor 10X1 protein is a Human Full Length protein, in the 1 to 309 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q8NGY0-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M K I N Q T I L K E F I L V G F S V Y P H V Q T F L F V V F F C L Y L L T L A G N L I I M G L T W V D R S L H T P M Y L F L S A L S F S E T C Y T L T I V P K M L E D L L A K D R S I S V T G C S L Q M C F F L G L G G T N C I I L T L M G Y D R F L A I C N P L R Y P L L M T N I V C G Q L V A S A C T A G F F I S L T E T A L I F R D S F C R P N L V K H F F C H M L A V I R L S C I D S N H T E F I I T L I S V S G L L G T L L L I I L T D V F I I S T V L R I P S A E G K Q K A F T T C A S H L T V V I I H F G F A S I V Y L K P E A S G D D T L I A V P Y T V I T P F L S P I I F S L R N K D M K N A F R R M M G N T V A L K K
- Accession
- Q8NGY0
- Protein length
- Full Length
- Amino acids
- 1 to 309
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Odorant receptor.
- Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Olfactory receptor 10X1 also known as OR10X1 is a protein involved in the detection of odorants. This receptor is part of the G-protein coupled receptor (GPCR) family and has a mass of around 34 kDa. OR10X1 is expressed predominantly in the olfactory epithelium located in the nasal cavity. It interacts with odor molecules initiating a cascade of intracellular signals leading to the perception of smell in the brain.
- Biological function summary
The receptor facilitates the first step of olfactory signal transduction by binding specific odorant molecules. Transduction involves coupling with G proteins which then activate adenylate cyclase to convert ATP to cAMP. This increase in cAMP opens cyclic nucleotide-gated ion channels resulting in changes in neuronal excitability that transmit signals to the brain. OR10X1 functions within a large family of olfactory receptors and does not exist alone; it is part of a vast network that distinguishes a wide array of smells.
- Pathways
The involvement of OR10X1 in the signaling of olfactory pathways begins with the detection of odorant molecules. The receptor plays a role in the olfactory signaling pathway interacting closely with G proteins such as G_olf which is specific to the olfactory system. Another critical pathway is the cAMP-dependent signaling where OR10X1 regulates neuronal response to environmental odor cues by modulating cAMP levels. These interactions allow for precise olfactory discrimination essential for survival.
- Associated diseases and disorders
Alterations in OR10X1 function or expression can relate to conditions like anosmia which is the loss of smell. Disruption in OR10X1 activity could also play a role in olfactory dysfunctions that appear in neurological diseases such as Alzheimer's disease. These diseases involve complex interactions with proteins like amyloid-beta or tau highlighting the critical role of olfactory receptors like OR10X1 in normal and diseased states.
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1 product image
SDS-PAGE - Recombinant Human Olfactory receptor 10X1 protein (ab165297)
ab165297 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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