Recombinant Human Olfactory receptor 2A2 protein

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The olfactory receptor 2A2 also known as OR2A2 functions as part of a larger family of G-protein-coupled receptors responsible for detecting odorants. This receptor has a molecular weight of approximately 35 kDa. OR2A2 is located predominantly in the olfactory epithelium which is part of the nasal cavity. It plays a role in the initial steps of olfactory signal transduction by binding specific molecules and converting these chemical signals into electrical signals that the brain interprets as different smells.

Biological function summary

The role of OR2A2 involves participating in odorant recognition and the sense of smell which are important components of the sensory system. Although OR2A2 does not form a complex itself it interacts with various other molecules in the olfactory signal transduction pathway to fulfill its role effectively. Its function depends on its ability to recognize and respond to a wide variety of chemical structures allowing organisms to detect and react to their environment through smell.

Pathways

OR2A2 aligns within the olfactory signaling pathway a part of the broader signal transduction super pathway. This pathway starts with odorant molecule binding and ends with a nerve impulse sent to the brain. OR2A2's function interacts closely with other receptors in the family and second messengers like cAMP and can also connect to related pathways involving adenylate cyclase. Through these interactions OR2A2 ensures precise and efficient olfactory signal processing.

Associated diseases and disorders

Researchers have identified certain conditions involving disruptions in olfactory signaling which might link to OR2A2. Though specific diseases directly associated with OR2A2 are not well-established its dysregulation could potentially relate to anosmia a condition where the sense of smell is partially or completely lost. Disorders affecting the olfactory system often implicate proteins like adenylate cyclase which is critical for downstream signaling events. Understanding the role of OR2A2 could provide insights into such sensory disorders.