Recombinant Human OLFML3 protein is a Human Full Length protein, in the 1 to 406 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M G P S T P L L I L F L L S W S G P L Q G Q Q H H L V E Y M E R R L A A L E E R L A Q C Q D Q S S R H A A E L R D F K N K M L P L L E V A E K E R E A L R T E A D T I S G R V D R L E R E V D Y L E T Q N P A L P C V E F D E K V T G G P G T K G K G R R N E K Y D M V T D C G Y T I S Q V R S M K I L K R F G G P A G L W T K D P L G Q T E K I Y V L D G T Q N D T A F V F P R L R D F T L A M A A R K A S R V R V P F P W V G T G Q L V Y G G F L Y F A R R P P G R P G G G G E M E N T L Q L I K F H L A N R T V V D S S V F P A E G L I P P Y G L T A D T Y I D L A A D E E G L W A V Y A T R E D D R H L C L A K L D P Q T L D T E Q Q W D T P C P R E N A E A A F V I C G T L Y V V Y N T R P A S R A R I Q C S F D A S G T L T P E R A A L P Y F P R R Y G A H A S L R Y N P R E R Q L Y A W D D G Y Q I V Y K L E M R K K E E E V
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.
Alternative names
PSEC0035, PSEC0173, PSEC0244, UNQ663/PRO1294, OLFML3, Olfactomedin-like protein 3, HNOEL-iso, hOLF44
Recommended products
Recombinant Human OLFML3 protein is a Human Full Length protein, in the 1 to 406 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q9NRN5-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M G P S T P L L I L F L L S W S G P L Q G Q Q H H L V E Y M E R R L A A L E E R L A Q C Q D Q S S R H A A E L R D F K N K M L P L L E V A E K E R E A L R T E A D T I S G R V D R L E R E V D Y L E T Q N P A L P C V E F D E K V T G G P G T K G K G R R N E K Y D M V T D C G Y T I S Q V R S M K I L K R F G G P A G L W T K D P L G Q T E K I Y V L D G T Q N D T A F V F P R L R D F T L A M A A R K A S R V R V P F P W V G T G Q L V Y G G F L Y F A R R P P G R P G G G G E M E N T L Q L I K F H L A N R T V V D S S V F P A E G L I P P Y G L T A D T Y I D L A A D E E G L W A V Y A T R E D D R H L C L A K L D P Q T L D T E Q Q W D T P C P R E N A E A A F V I C G T L Y V V Y N T R P A S R A R I Q C S F D A S G T L T P E R A A L P Y F P R R Y G A H A S L R Y N P R E R Q L Y A W D D G Y Q I V Y K L E M R K K E E E V
- Accession
- Q9NRN5
- Protein length
- Full Length
- Amino acids
- 1 to 406
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.
- Sequence similarities
Belongs to the OLFML3 family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
OLFML3 also known as Olfactomedin-like protein 3 is a secreted glycoprotein with a molecular mass of approximately 50 kDa. It belongs to the olfactomedin domain-containing protein family. This protein mainly expresses in various tissues including the eyes brain and heart. It often emerges in areas involved in development and growth contributing to its functional significance in different physiological contexts.
- Biological function summary
OLFML3 plays an integral role in cell adhesion and development processes. It acts as a regulatory molecule facilitating cell communication in tissue development. Studies suggest its involvement in promoting angiogenesis the formation of new blood vessels thereby assisting in tissue repair and regeneration. OLFML3 may associate with components of the extracellular matrix suggesting its potential presence in larger protein complexes that modulate cellular environments.
- Pathways
OLFML3 significantly interacts in pathways related to angiogenesis and tissue remodeling. It plays a role in the VEGF (Vascular Endothelial Growth Factor) signaling pathway which is critical for angiogenesis. OLFML3 functions alongside proteins like VEGFR2 enhancing the process of new blood vessel formation in response to hypoxic conditions or injury which is essential in maintaining tissue homeostasis and repair.
- Associated diseases and disorders
Researchers link OLFML3 to cardiovascular diseases and cancer progression. An overexpression of OLFML3 has been observed in certain cancers where it may promote tumor angiogenesis aiding in cancer growth and metastasis. Additionally disruptions in its function could associate with abnormal heart developments implicating its relationship with proteins like MMPs (matrix metalloproteinases) that participate in matrix remodeling processes involved in both tumor and cardiovascular pathology.
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1 product image
SDS-PAGE - Recombinant Human OLFML3 protein (ab163444)
ab163444 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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