Recombinant Human Olig3 protein is a Human Full Length protein, in the 1 to 272 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
Wheat germ
- Tags
GST tag N-Terminus
- Applications
ELISA, WB
- Biologically active
No
Amino acid sequence
M N S D S S S V S S R A S S P D M D E M Y L R D H H H R H H H H Q E S R L N S V S S T Q G D M M Q K M P G E S L S R A G A K A A G E S S K Y K I K K Q L S E Q D L Q Q L R L K I N G R E R K R M H D L N L A M D G L R E V M P Y A H G P S V R K L S K I A T L L L A R N Y I L M L T S S L E E M K R L V G E I Y G G H H S A F H C G T V G H S A G H P A H A A N S V H P V H P I L G G A L S S G N A S S P L S A A S L P A I G T I R P P H S L L K A P S T P P A L Q L G S G F Q H W A G L P C P C T I C Q M P P P P H L S A L S T A N M A R L S A E S K D L L K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.
Alternative names
BHLHB7, BHLHE20, BHLHB7, OLIG3, BHLHE20, Oligodendrocyte transcription factor 3, Oligo3, Class B basic helix-loop-helix protein 7, Class E basic helix-loop-helix protein 20, bHLHb7, bHLHe20
Recommended products
Recombinant Human Olig3 protein is a Human Full Length protein, in the 1 to 272 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
Wheat germ
- Tags
GST tag N-Terminus
- Applications
ELISA, WB
- Biologically active
No
- Accession
- Q7RTU3-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
M N S D S S S V S S R A S S P D M D E M Y L R D H H H R H H H H Q E S R L N S V S S T Q G D M M Q K M P G E S L S R A G A K A A G E S S K Y K I K K Q L S E Q D L Q Q L R L K I N G R E R K R M H D L N L A M D G L R E V M P Y A H G P S V R K L S K I A T L L L A R N Y I L M L T S S L E E M K R L V G E I Y G G H H S A F H C G T V G H S A G H P A H A A N S V H P V H P I L G G A L S S G N A S S P L S A A S L P A I G T I R P P H S L L K A P S T P P A L Q L G S G F Q H W A G L P C P C T I C Q M P P P P H L S A L S T A N M A R L S A E S K D L L K
- Accession
- Protein length
Full Length
- Amino acids
1 to 272
- Nature
Recombinant
- Tags
GST tag N-Terminus
Specifications
- Form
Liquid
General info
- Function
May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.
- Subcellular localisation
Nucleus
Storage
- Shipped at conditions
Dry Ice
- Appropriate short-term storage conditions
-80°C
- Appropriate long-term storage conditions
-80°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
U+00A0;
U+00A0;
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Olig3 also known as Oligodendrocyte transcription factor 3 acts as a basic helix-loop-helix (bHLH) transcription factor. It has a mass of about 31 kDa and plays an important role in regulating gene expression. You typically find it expressed in developing neural tissues especially in the central nervous system. In humans it is located on chromosome 6 where its precise control is necessary for proper neural development.
- Biological function summary
Olig3 regulates the development of specific neurons in the central nervous system. It does not operate alone but often forms heterodimers with other bHLH transcription factors to exert its influence. Researchers have shown its involvement in neurogenesis particularly in defining neuronal cell fate. By activating or repressing specific genes it fine-tunes the development of neural progenitor cells into specialized neuron types.
- Pathways
Olig3 integrates into the Notch and Sonic Hedgehog signaling pathways. It influences neuronal differentiation through these pathways often interacting with proteins like Hes1 which is part of the Notch pathway. Sonic Hedgehog also plays a role in guiding the spatial expression patterns where Olig3 is active ensuring a balanced developmental process. These pathways are essential for the correct propagation of signals that dictate the specification of neuronal cell lineages.
- Associated diseases and disorders
Olig3 has been implicated in medulloblastoma and certain developmental disorders. Dysregulation of Olig3 expression and function can contribute to tumor formation in the cerebellum often in conjunction with associated proteins such as Gli1 from the Sonic Hedgehog pathway. Abnormalities in Olig3 expression may also link to developmental neuroissues due to its foundational role in neuron formation and differentiation.
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1 product image
SDS-PAGE - Recombinant Human Olig3 protein (ab165797)
ab165797 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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