Recombinant Human Oligodendrocyte Specific Protein is a Human Full Length protein, in the 1 to 207 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M V A T C L Q V V G F V T S F V G W I G V I V T T S T N D W V V T C G Y T I P T C R K L D E L G S K G L W A D C V M A T G L Y H C K P L V D I L I L P G Y V Q A C R A L M I A A S V L G L P A I L L L L T V L P C I R M G Q E P G V A K Y R R A Q L A G V L L I L L A L C A L V A T I W F P V C A H R E T T I V S F G Y S L Y A G W I G A V L C L V G G C V I L C C A G D A Q A F G E N R F Y Y T A G S S S P T H A K S A H V
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes (Recombinant protein). |
Target data
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Alternative names
OSP, OTM, CLDN11, Claudin-11, Oligodendrocyte-specific protein
Recommended products
Recombinant Human Oligodendrocyte Specific Protein is a Human Full Length protein, in the 1 to 207 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- O75508-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M V A T C L Q V V G F V T S F V G W I G V I V T T S T N D W V V T C G Y T I P T C R K L D E L G S K G L W A D C V M A T G L Y H C K P L V D I L I L P G Y V Q A C R A L M I A A S V L G L P A I L L L L T V L P C I R M G Q E P G V A K Y R R A Q L A G V L L I L L A L C A L V A T I W F P V C A H R E T T I V S F G Y S L Y A G W I G A V L C L V G G C V I L C C A G D A Q A F G E N R F Y Y T A G S S S P T H A K S A H V
- Accession
- O75508
- Protein length
- Full Length
- Predicted molecular weight
- 48.4 kDa
- Amino acids
- 1 to 207
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
- Sequence similarities
Belongs to the claudin family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
O75508
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Oligodendrocyte Specific Protein also known as O4 or O4 protein is an important marker for oligodendrocytes. This protein has a mass of approximately 24 kDa. Predominantly it is expressed in the central nervous system (CNS) specifically in oligodendrocyte precursor cells (OPCs) and mature oligodendrocytes. Its presence marks the differentiation stage of oligodendrocytes serving as an indicator of their development and maturation.
- Biological function summary
The oligodendrocyte marker O4 plays a significant role in the myelination process supporting the formation of the myelin sheath around neurons. O4 does not act as part of a complex but is essential in the identification of oligodendrocyte lineage cells. During development it signals the transition of OPCs into mature myelinating oligodendrocytes which are necessary for effective neuronal signal transmission in the CNS.
- Pathways
Oligodendrocyte marker O4 influences critical processes in the nervous system namely the myelination pathway. It interacts with various proteins including myelin basic protein (MBP) involved in the formation and maintenance of the myelin sheath. The presence of O4 marks the progression along the oligodendrocyte lineage and fits within the larger framework of CNS development and repair indicating a healthy state of neuronal insulation.
- Associated diseases and disorders
Disruptions involving the oligodendrocyte marker O4 can relate to multiple sclerosis (MS) and leukodystrophies. These conditions arise from demyelination or abnormal myelination respectively. O4 in association with other proteins like MBP and proteolipid protein (PLP) can serve as a biomarker for disease activity and progression. Its expression levels may assist in the research and diagnosis of demyelinating diseases.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human Oligodendrocyte Specific Protein (ab131748)
12.5% SDS-PAGE analysis of ab131748, stained with Coomassie Blue.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com