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AB131748

Recombinant Human Oligodendrocyte Specific Protein (GST tag N-Terminus)

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Recombinant Human Oligodendrocyte Specific Protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 207 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

OSP, OTM, CLDN11, Claudin-11, Oligodendrocyte-specific protein

1 Images
SDS-PAGE - Recombinant Human Oligodendrocyte Specific Protein (GST tag N-Terminus) (AB131748)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Oligodendrocyte Specific Protein (GST tag N-Terminus) (AB131748)

12.5% SDS-PAGE analysis of ab131748, stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE, ELISA, WB

applications

Biologically active

No

Accession

O75508

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB175236

Anti-Oligodendrocyte Specific Protein antibody [EPR12726] - Oligodendrocyte Marker

RabMAb|Recombinant|Lab Essentials

Flow Cytometry - Anti-Oligodendrocyte Specific Protein antibody [EPR12726] - Oligodendrocyte Marker (AB175236)

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Proteins & Peptides

AB316501

Recombinant Human CD3 Epsilon Protein Standard (His tag)

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Proteins & Peptides

AB63280

Recombinant Human Stanniocalcin 1/STC protein

SDS-PAGE - Recombinant Human Stanniocalcin 1/STC protein (AB63280)

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Proteins & Peptides

AB276539

Recombinant Human APOA1BP protein (His tag)

SDS-PAGE - Recombinant Human APOA1BP protein (His tag) (AB276539)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>(Recombinant protein).</p>" } } }
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Product details

O75508
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Sequence info

[{"sequence":"MVATCLQVVGFVTSFVGWIGVIVTTSTNDWVVTCGYTIPTCRKLDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGQEPGVAKYRRAQLAGVLLILLALCALVATIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVILCCAGDAQAFGENRFYYTAGSSSPTHAKSAHV","proteinLength":"Full Length","predictedMolecularWeight":"48.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":207,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O75508","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Oligodendrocyte Specific Protein also known as O4 or O4 protein is an important marker for oligodendrocytes. This protein has a mass of approximately 24 kDa. Predominantly it is expressed in the central nervous system (CNS) specifically in oligodendrocyte precursor cells (OPCs) and mature oligodendrocytes. Its presence marks the differentiation stage of oligodendrocytes serving as an indicator of their development and maturation.
Biological function summary

The oligodendrocyte marker O4 plays a significant role in the myelination process supporting the formation of the myelin sheath around neurons. O4 does not act as part of a complex but is essential in the identification of oligodendrocyte lineage cells. During development it signals the transition of OPCs into mature myelinating oligodendrocytes which are necessary for effective neuronal signal transmission in the CNS.

Pathways

Oligodendrocyte marker O4 influences critical processes in the nervous system namely the myelination pathway. It interacts with various proteins including myelin basic protein (MBP) involved in the formation and maintenance of the myelin sheath. The presence of O4 marks the progression along the oligodendrocyte lineage and fits within the larger framework of CNS development and repair indicating a healthy state of neuronal insulation.

Disruptions involving the oligodendrocyte marker O4 can relate to multiple sclerosis (MS) and leukodystrophies. These conditions arise from demyelination or abnormal myelination respectively. O4 in association with other proteins like MBP and proteolipid protein (PLP) can serve as a biomarker for disease activity and progression. Its expression levels may assist in the research and diagnosis of demyelinating diseases.
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Specifications

Form

Liquid

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General info

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Sequence similarities

Belongs to the claudin family.

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Product protocols

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Target data

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
See full target information CLDN11
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Product promise

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