Recombinant human Oncostatin M/OSM protein (Active)
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Recombinant human Oncostatin M/OSM protein (Active) is a Human Full Length protein, in the 26 to 221 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS, Mass Spec, HPLC, Cell Culture.
View Alternative Names
Oncostatin-M, OSM
- FuncS
Supplier Data
Functional Studies - Recombinant human Oncostatin M/OSM protein (Active) (AB270077)
Fully biologically active when compared to standard. Determined by the dose dependant proliferation of TF-1 cell line.
ED50 is ≤ 0.2ng/mL, corresponding to a specific activity of 5.00 x 106 units/mg.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant human Oncostatin M/OSM protein (Active) (AB270077)
(M - 2Arg) + 0.8 Da (expected mass after Arg loss due to transpeptidation 21896 Da; +16 Da : Hydroxylation/Oxidation, +32 Da : dioxidation; +203 Da HexNAc, + 365 Da Hex(1)HexNAc(1).
Calc MW is 22208.41 Da.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant human Oncostatin M/OSM protein (Active) (AB270077)
(M - 2Arg) + 0.8 Da (expected mass after Arg loss due to transpeptidation 21896 Da; +16 Da : Hydroxylation/Oxidation, +32 Da : dioxidation; +203 Da HexNAc, + 365 Da Hex(1)HexNAc(1)
Calc MW is 22208.41 Da.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human Oncostatin M/OSM protein (Active) (AB270077)
SDS-PAGE - Recombinant human Oncostatin M/OSM protein (Active) (ab270077).
Purity ≥95%.
- HPLC
Supplier Data
HPLC - Recombinant human Oncostatin M/OSM protein (Active) (AB270077)
Purity by HPLC ≥95%.
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Oncostatin M modulates a range of cellular activities including cell proliferation differentiation and apoptosis. This cytokine affects diverse cell types such as fibroblasts endothelial cells and epithelial cells showing particular influence in processes like tissue remodeling and immune response. It acts as a monomer and does not need assembly into a larger complex to exert its function. Its ability to trigger gene expression differentiates it from other closely related cytokines.
Pathways
Oncostatin M involves itself in significant pathways like the JAK/STAT signaling pathway and the MAPK pathway. Through these pathways it promotes signal transduction essential for immune regulation and cellular response to external stimuli. OSM interacts with proteins like the gp130 receptor a common signaling component for cytokine receptors in its family and influences downstream effectors involved in these pathways.
Specifications
Form
Lyophilized
Additional notes
Purity =95% by HPLC.
General info
Function
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).
Sequence similarities
Belongs to the LIF/OSM family.
Post-translational modifications
Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.
Target data
Complementary Products
Proteins & Peptides
AB259377
Recombinant Human Interferon gamma protein (Active)
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