Recombinant Human Opticin protein (denatured) (His tag N-Terminus)
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Recombinant Human Opticin protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 20 to 332 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
View Alternative Names
OPT, OPTC, Opticin, Oculoglycan
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Opticin protein (denatured) (His tag N-Terminus) (AB202160)
15% SDS-PAGE analysis of ab202160 (3μg).
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Opticin protein (denatured) (AB202160)
3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Opticin plays a role in maintaining eye health by modulating cell adhesion and inhibiting angiogenesis. It contributes to preventing unwanted blood vessel growth in ocular tissues which can lead to complications. Opticin is not part of a larger protein complex but it interacts dynamically with the extracellular matrix and other matrix-associated proteins that include vitronectin and thrombospondin.
Pathways
Opticin participates in pathways regulating tissue remodeling and vascular development. Within the extracellular matrix organization pathway opticin works with proteins such as fibronectin and decorin to maintain tissue integrity. Additionally opticin contributes to the angiogenesis inhibition pathway where it helps to regulate new blood vessel formation alongside thrombospondin-1 acting as an inhibitor of angiogenic processes.
Specifications
Form
Liquid
Additional notes
ab202160 was purified by conventional chromatography techniques.
General info
Function
Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity).
Sequence similarities
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
Post-translational modifications
O-glycosylated.. Proteolytically cleaved by MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, ADAMTS4, and ADAMTS5 (PubMed:23845380). Proteolytically cleaved by MMP13 (By similarity). The degradation of OPTC by proteases may contribute to osteoarthritis pathophysiology (PubMed:23845380).. Sulfated on tyrosine residues.
Target data
Complementary Products
Product promise
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