Recombinant Human Orexin Receptor 1/Ox-1-R protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Orexin receptors regulate energy homeostasis and alertness. Ox-1-R is involved in the control of wakefulness and appetite as it interacts with neurotransmitters such as noradrenaline and histamine. Ox-1-R does not function in isolation; it works in tandem with other receptors and proteins including orexin receptor 2 to form integrated networks for maintaining physiological balance. Their role in the central nervous system is essential for coordinating physical and mental activity.

Pathways

Orexin 1 receptor participates in the neuropeptide signaling pathways and sleep regulation mechanisms. Orexin receptors take part in the hypothalamic neuropeptide pathways interacting with other proteins like melanin-concentrating hormone and corticotropin-releasing factor facilitating the control of sleep and feeding cycles. These interactions underline the receptor’s regulatory functions on metabolic and circadian rhythm processes ensuring organismal adaptation to varying environmental cues.