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AB235879

Recombinant Human OSCAR/Osteoclast-associated receptor protein (His tag)

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Recombinant Human OSCAR/Osteoclast-associated receptor protein (His tag) is a Human Full Length protein, in the 19 to 282 aa range, expressed in Baculovirus infected insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Osteoclast-associated immunoglobulin-like receptor, Osteoclast-associated receptor, hOSCAR, Polymeric immunoglobulin receptor 3, PIgR-3, PIgR3, Poly-Ig receptor 3, OSCAR

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SDS-PAGE - Recombinant Human OSCAR/Osteoclast-associated receptor protein (His tag) (AB235879)
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Supplier Data

SDS-PAGE - Recombinant Human OSCAR/Osteoclast-associated receptor protein (His tag) (AB235879)

15% SDS-PAGE analysis of 3 μg ab235879.

40-57 kDa (Under reducing conditions)

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Baculovirus infected insect cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8IYS5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as OSCAR
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Sequence info

[{"sequence":"DITPSVPPASYHPKPWLGAQPATVVTPGVNVTLRCRAPQPAWRFGLFKPGEIAPLLFRDVSSELAEFFLEEVTPAQGGSYRCCYRRPDWGPGVWSQPSDVLELLVTEELPRPSLVALPGPVVGPGANVSLRCAGRLRNMSFVLYREGVAAPLQYRHSAQPWADFTLLGARAPGTYSCYYHTPSAPYVLSQRSEVLVISWEGEGPEARPASSAPGMQAPGPPPSDPGAQAPSLSSFRPRGLVLQPLLPQTQDSWDPAPPPSDPGVHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"29.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":282,"aminoAcidStart":19,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"Q8IYS5","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The osteoclast-associated receptor (OSCAR) is a cell surface receptor known for its role in osteoclastogenesis. Alternative names for OSCAR include OC-STAMP and PSL. This receptor is a type I transmembrane protein with a mass of approximately 45 kDa. It is expressed on the surface of precursor osteoclast cells and to a lesser extent certain immune cells like macrophages and dendritic cells. Its structure includes two immunoglobulin-like domains that contribute to its function in cellular signaling.
Biological function summary

OSCAR plays a critical role in the differentiation and activation of osteoclasts which are cells involved in bone resorption. OSCAR forms part of an important signaling complex that interacts with adaptor proteins such as FcRγ triggering downstream signaling cascades. Its activation drives the expression of genes necessary for osteoclast development linking it to bone homeostasis and remodeling. OSCAR functions alongside other receptors to ensure proper skeletal maintenance.

Pathways

OSCAR's function is integrated into the RANK/RANKL pathway which is pivotal for osteoclast differentiation. The interaction of OSCAR with the FcRγ chain activates signaling pathways similar to those triggered by the RANK receptor. These include NF-κB and MAPK pathways which promote osteoclast maturation and activity. OSCAR also interacts indirectly with proteins like TRAF6 contributing to the regulation of bone metabolism.

OSCAR's function connects to conditions such as osteoporosis and rheumatoid arthritis. In osteoporosis imbalanced bone remodeling results in weakened bones where OSCAR's overactivity contributes to increased bone resorption. In rheumatoid arthritis aberrant OSCAR expression may worsen joint damage due to excessive osteoclast activity. The receptor also interacts with proteins implicated in these diseases like RANK and OPG influencing pathological processes in bone and joint tissues.
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Specifications

Form

Liquid

Additional notes

Affinity purified

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General info

Function

Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.

Sequence similarities

Belongs to the leukocyte receptor complex/polymeric immunoglobulin receptor (PIR/LRC) family.

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Product protocols

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Target data

Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.
See full target information OSCAR
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