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AB162283

Recombinant Human OSGIN1 protein

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Recombinant Human OSGIN1 protein is a Human Full Length protein, in the 1 to 477 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

BDGI, OKL38, OSGIN1, Oxidative stress-induced growth inhibitor 1, Bone marrow stromal cell-derived growth inhibitor, Pregnancy-induced growth inhibitor OKL38, BMSC-derived growth inhibitor, huOKL38

1 Images
SDS-PAGE - Recombinant Human OSGIN1 protein (AB162283)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human OSGIN1 protein (AB162283)

ab162283 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q9UJX0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSSSRKDHLGASSSEPLPVIIVGNGPSGICLSYLLSGYTPYTKPDAIHPHPLLQRKLTEAPGVSILDQDLDYLSEGLEGRSQSPVALLFDALLRPDTDFGGNMKSVLTWKHRKEHAIPHVVLGRNLPGGAWHSIEGSMVILSQGQWMGLPDLEVKDWMQKKRRGLRNSRATAGDIAHYYRDYVVKKGLGHNFVSGAVVTAVEWGTPDPSSCGAQDSSPLFQVSGFLTRNQAQQPFSLWARNVVLATGTFDSPARLGIPGEALPFIHHELSALEAATRVGAVTPASDPVLIIGAGLSAADAVLYARHYNIPVIHAFRRAVDDPGLVFNQLPKMLYPEYHKVHQMMREQSILSPSPYEGYRSLPRHQLLCFKEDCQAVFQDLEGVEKVFGVSLVLVLIGSHPDLSFLPGAGADFAVDPDQPLSAKRNPIDVDPFTYQSTRQEGLYAMGPLAGDNFVRFVQGGALAVASSLLRKETRKPP","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":477,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9UJX0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The OSGIN1 gene also known as Oxidative Stress Induced Growth Inhibitor 1 encodes a protein that weighs approximately 56 kDa. This protein plays an important role in cellular response to oxidative stress. It is expressed in various tissues including the liver kidney and brain. The OSGIN1 protein functions by inducing apoptosis when oxidative stress is detected aiding the cell in managing damage from reactive oxygen species.
Biological function summary

The ability of OSGIN1 to regulate cell death allows it to maintain cellular homeostasis. This protein does not operate as part of a complex but performs its functions by altering the transcription of specific genes involved in cell growth and death. By modulating genes linked to oxidative damage OSGIN1 controls balance between cell survival and apoptosis thereby influencing cell fate in stressful environments.

Pathways

OSGIN1 plays a significant role in the oxidative stress response pathway by interacting with key proteins such as p53 and Nrf2. These interactions facilitate the antioxidant responses of cells. By promoting p53-mediated apoptosis and Nrf2-related antioxidant gene expression OSGIN1 helps in protecting cells from oxidative damage contributing to the proper functioning of related pathways.

The dysregulation of OSGIN1 is associated with conditions like cancer and neurodegenerative diseases. Aberrant expression of OSGIN1 can lead to either excessive cell death or survival contributing to tumorigenesis in various cancers. Additionally in neurodegenerative disorders OSGIN1 dysfunction can disrupt neuronal survival. The protein connects with dysregulated p53 activity in cancer and Nrf2 pathway alterations in neurodegenerative diseases influencing disease progression.
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Specifications

Form

Liquid

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General info

Function

Regulates the differentiation and proliferation through the regulation of cell death.

Sequence similarities

Belongs to the OKL38 family.

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Product protocols

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Target data

Regulates the differentiation and proliferation through the regulation of cell death.
See full target information OSGIN1
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Product promise

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