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AB183242

Recombinant Human OSR2 protein (denatured)

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Recombinant Human OSR2 protein (denatured) is a Human Full Length protein, in the 1 to 276 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.

View Alternative Names

Protein odd-skipped-related 2, OSR2

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SDS-PAGE - Recombinant Human OSR2 protein (denatured) (AB183242)
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Supplier Data

SDS-PAGE - Recombinant Human OSR2 protein (denatured) (AB183242)

15% SDS-PAGE analysis of ab183242 (3μg).

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8N2R0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMGSKALPAPIPLHPSLQLTNYSFLQAVNTFPATVDHLQGLYGLSAVQTMHMNHWTLGYPNVHEITRSTITEMAAAQGLVDARFPFPALPFTTHLFHPKQGAIAHVLPALHKDRPRFDFANLAVAATQEDPPKMGDLSKLSPGLGSPISGLSKLTPDRKPSRGRLPSKTKKEFICKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHMQTSSPTAASSAAKCSGETVICGGTA","proteinLength":"Full Length","predictedMolecularWeight":"33 kDa","actualMolecularWeight":null,"aminoAcidEnd":276,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8N2R0","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OSR2 also known as odd-skipped related 2 encodes a transcription factor with a mass of approximately 32 kDa. OSR2 expresses in tissues such as mesoderm and ectoderm during embryonic development and is later present in specific organs like the kidney. It plays an important role in gene regulation affecting the transcription of several downstream targets important for tissue differentiation.
Biological function summary

The transcription factor activity influences the development of cartilage and bone through its regulatory functions. OSR2 does not function as part of a larger complex; rather it interacts with multiple other transcription factors and regulatory proteins within cells. Its expression pattern indicates a role in defining structural morphogenesis where OSR2 guides cellular differentiation and contributes significantly to the proper formation of skeletal elements.

Pathways

OSR2 participates in the Wnt signaling pathway and bone morphogenetic protein (BMP) pathway. In the Wnt pathway OSR2 regulates gene expression necessary for cell polarity and organ development. In the BMP pathway its regulatory functions affect bone formation and osteogenic differentiation alongside other proteins such as Smad and Runx2 integrating signals for tissue development.

Abnormalities in OSR2 expression or function associate with congenital malformations such as craniofacial disorders and renal dysplasia. These malformations often involve interactions with the protein MSX2 and other transcriptional regulators. By influencing the expression levels of key developmental genes OSR2 disruptions contribute to specific disease phenotypes making it a target of interest for therapeutic research and interventions.
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Specifications

Form

Liquid

Additional notes

ab183242 was purified using conventional chromatography techniques.

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General info

Function

May be involved in the development of the mandibular molar tooth germ at the bud stage.

Sequence similarities

Belongs to the Odd C2H2-type zinc-finger protein family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

May be involved in the development of the mandibular molar tooth germ at the bud stage.
See full target information Protein odd-skipped-related 2
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