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AB165873

Recombinant Human OSTA protein

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Recombinant Human OSTA protein is a Human Full Length protein, in the 1 to 340 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

OSTA, SLC51A, Organic solute transporter subunit alpha, OST-alpha, Solute carrier family 51 subunit alpha

1 Images
SDS-PAGE - Recombinant Human OSTA protein (AB165873)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human OSTA protein (AB165873)

ab165873 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q86UW1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MEPGRTQIKLDPRYTADLLEVLKTNYGIPSACFSQPPTAAQLLRALGPVELALTSILTLLALGSIAIFLEDAVYLYKNTLCPIKRRTLLWKSSAPTVVSVLCCFGLWIPRSLVLVEMTITSFYAVCFYLLMLVMVEGFGGKEAVLRTLRDTPMMVHTGPCCCCCPCCPRLLLTRKKLQLLMLGPFQYAFLKITLTLVGLFLVPDGIYDPADISEGSTALWINTFLGVSTLLALWTLGIISRQARLHLGEQNMGAKFALFQVLLILTALQPSIFSVLANGGQIACSPPYSSKTRSQVMNCHLLILETFLMTVLTRMYYRRKDHKVGYETFSSPDLDLNLKA","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":340,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q86UW1","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein "OSTA" plays a significant role in cellular processes through its structural and functional characteristics. Its alternate names include "Osteocalcin Transporter Associated" and "OST-alpha." The molecular mass of OSTA is approximately 40 kDa. The protein is mainly expressed in the intestinal epithelium liver and kidneys suggesting it has a role in nutrient absorption and detoxification. It operates as a transporter facilitating the movement of various molecules across cell membranes.
Biological function summary

OSTA contributes to maintaining homeostasis by transporting bile acids and sterols. It functions within a larger complex known as the heteromeric organic solute transporter comprising OST-alpha and OST-beta subunits. This complex plays a critical role in enterohepatic circulation which manages the recapture and redistribution of bile acids from the intestine to the liver thereby maintaining lipid metabolism balance.

Pathways

OSTA impacts the enterohepatic circulation pathway and interacts with proteins such as NR1H4 (or FXR) to regulate bile acid levels. In the lipid metabolism pathway its ability to facilitate bile acid transport connects it to cholesterol homeostasis influencing absorption and excretion. Its operation alongside proteins like OST-beta further accentuates how it modulates these pathways sustaining systemic cholesterol levels.

Alterations in OSTA expression or function associate with conditions like cholestasis and metabolic syndrome. Cholestasis involves impaired bile flow where OSTA malfunction can exacerbate cholesterol buildup. In metabolic syndrome it influences lipid distribution in the body. Interactions with proteins like FXR highlight its role in these conditions linking OSTA malfunctions with disrupted metabolic function and disease progression.
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Specifications

Form

Liquid

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General info

Function

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed : 16317684). Efficiently transports the major species of bile acids (taurocholate) (PubMed : 16317684). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (PubMed : 16317684). Able to transport eicosanoids such as prostaglandin E2 (By similarity).

Sequence similarities

Belongs to the OST-alpha family.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed : 16317684). Efficiently transports the major species of bile acids (taurocholate) (PubMed : 16317684). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (PubMed : 16317684). Able to transport eicosanoids such as prostaglandin E2 (By similarity).
See full target information SLC51A
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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