JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB87058

Recombinant Human OSTF1 protein (His tag C-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human OSTF1 protein (His tag C-Terminus) is a Human Full Length protein, in the 1 to 217 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

View Alternative Names

Osteoclast-stimulating factor 1, OSTF1

1 Images
SDS-PAGE - Recombinant Human OSTF1 protein (His tag C-Terminus) (AB87058)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human OSTF1 protein (His tag C-Terminus) (AB87058)

ab87058 on 15% SDS-PAGE (3μg)

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q92882

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0077% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

Complementary Products

Primary Antibodies

AB202901

Anti-OSTF1 antibody [EP15457]

RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OSTF1 antibody [EP15457] (AB202901)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MSKPPPKPVKPGEGGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLFLAKGARTDLRNIEKKLAFDMATNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSDLEHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":217,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q92882","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OSTF1 also known as Osteoclast-Stimulating Factor 1 is an important protein involved in the regulation of bone resorption. It has a molecular weight of approximately 60 kDa. OSTF1 is widely expressed in bone tissues where it influences the activity of osteoclasts. Researchers have identified it as a cytoplasmic protein that plays a role in signaling processes. OSTF1 functions as an adapter protein linking other proteins involved in cellular functions related to bone metabolism.
Biological function summary

OSTF1 interacts with cytoskeleton-associated proteins to enhance osteoclast activity. It coordinates the assembly of protein complexes essential for cell movement and actin cytoskeleton organization. OSTF1 is known to engage in complex formations with proteins such as Src a tyrosine kinase that facilitates its regulatory activities in osteoclasts. This interaction highlights OSTF1's role in the dynamics of cell adhesion and mobility which are important for bone remodeling processes.

Pathways

OSTF1 plays a role in the RANK/RANKL/OPG signaling pathway an important pathway for bone homeostasis. It partners with the Src protein in this pathway influencing osteoclast differentiation and activation. Besides OSTF1 is linked to the integrin signaling pathway through its interactions with cytoskeleton components which is equally significant for cell adhesion and survival. By mediating these interactions OSTF1 helps modulate the balance between formation and breakdown of bone matrix.

OSTF1 has associations with osteoporosis and Paget’s disease of bone. In osteoporosis the deregulation of OSTF1 influences abnormal osteoclast activity leading to increased bone resorption and fragility. In Paget’s disease OSTF1 may interact with other proteins like TNF receptor-associated factor 6 (TRAF6) affecting the excessive breakdown and formation of bone. The involvement of OSTF1 in these conditions makes it a target of interest for therapeutic interventions in bone diseases.
style
left-column

Specifications

Form

Liquid

Additional notes

ab87058 was purified using conventional chromatography techniques.

style
left-column

General info

Function

Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.

style
left-column

Product protocols

style
left-column

Target data

Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
See full target information Osteoclast-stimulating factor 1
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com