Recombinant Human OSTF1 protein is a Human Full Length protein, in the 1 to 217 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M S K P P P K P V K P G E G G Q V K V F R A L Y T F E P R T P D E L Y F E E G D I I Y I T D M S D T N W W K G T S K G R T G L I P S N Y V A E Q A E S I D N P L H E A A K R G N L S W L R E C L D N R V G V N G L D K A G S T A L Y W A C H G G H K D I V E M L F T Q P N I E L N Q Q N K L G D T A L H A A A W K G Y A D I V Q L F L A K G A R T D L R N I E K K L A F D M A T N A A C A S L L K K K Q G T D A V R T L S N A E D Y L D D E D S D L E H H H H H H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
Alternative names
Osteoclast-stimulating factor 1, OSTF1
Recommended products
Recombinant Human OSTF1 protein is a Human Full Length protein, in the 1 to 217 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q92882-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0077% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M S K P P P K P V K P G E G G Q V K V F R A L Y T F E P R T P D E L Y F E E G D I I Y I T D M S D T N W W K G T S K G R T G L I P S N Y V A E Q A E S I D N P L H E A A K R G N L S W L R E C L D N R V G V N G L D K A G S T A L Y W A C H G G H K D I V E M L F T Q P N I E L N Q Q N K L G D T A L H A A A W K G Y A D I V Q L F L A K G A R T D L R N I E K K L A F D M A T N A A C A S L L K K K Q G T D A V R T L S N A E D Y L D D E D S D L E H H H H H H
- Accession
- Q92882
- Protein length
- Full Length
- Amino acids
- 1 to 217
- Nature
- Recombinant
Specifications
- Form
- Liquid
- Additional notes
ab87058 was purified using conventional chromatography techniques.
General info
- Function
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
OSTF1 also known as Osteoclast-Stimulating Factor 1 is an important protein involved in the regulation of bone resorption. It has a molecular weight of approximately 60 kDa. OSTF1 is widely expressed in bone tissues where it influences the activity of osteoclasts. Researchers have identified it as a cytoplasmic protein that plays a role in signaling processes. OSTF1 functions as an adapter protein linking other proteins involved in cellular functions related to bone metabolism.
- Biological function summary
OSTF1 interacts with cytoskeleton-associated proteins to enhance osteoclast activity. It coordinates the assembly of protein complexes essential for cell movement and actin cytoskeleton organization. OSTF1 is known to engage in complex formations with proteins such as Src a tyrosine kinase that facilitates its regulatory activities in osteoclasts. This interaction highlights OSTF1's role in the dynamics of cell adhesion and mobility which are important for bone remodeling processes.
- Pathways
OSTF1 plays a role in the RANK/RANKL/OPG signaling pathway an important pathway for bone homeostasis. It partners with the Src protein in this pathway influencing osteoclast differentiation and activation. Besides OSTF1 is linked to the integrin signaling pathway through its interactions with cytoskeleton components which is equally significant for cell adhesion and survival. By mediating these interactions OSTF1 helps modulate the balance between formation and breakdown of bone matrix.
- Associated diseases and disorders
OSTF1 has associations with osteoporosis and Paget’s disease of bone. In osteoporosis the deregulation of OSTF1 influences abnormal osteoclast activity leading to increased bone resorption and fragility. In Paget’s disease OSTF1 may interact with other proteins like TNF receptor-associated factor 6 (TRAF6) affecting the excessive breakdown and formation of bone. The involvement of OSTF1 in these conditions makes it a target of interest for therapeutic interventions in bone diseases.
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1 product image
SDS-PAGE - Recombinant Human OSTF1 protein (ab87058)
ab87058 on 15% SDS-PAGE (3μg)
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