Recombinant Human Otoraplin protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Otoraplin also known as Otoraplin A is a protein with a molecular mass of approximately 14 kDa. It belongs to the fibroblast growth factor (FGF) family and is mainly expressed in the ear especially in the cochlear and vestibular tissues. Otoraplin acts mechanically through its involvement in cellular signaling processes. Although studied less extensively its presence in neural tissues indicates that it might contribute to the developing auditory and equilibrium systems.

Biological function summary

This protein assists in cell proliferation survival and differentiation within ear tissues. The precise role is not fully determined yet but its membership in the protein family suggests that it might interact with others in similar contexts. Otoraplin does not seem part of a large complex but likely still has interactions as part of signaling networks important to tissue maintenance and function.

Pathways

Otoraplin appears implicated in the fibroblast growth factor signaling pathway. This pathway is essential for various cellular processes including development and wound healing. In this pathway proteins like FGFR1 (Fibroblast Growth Factor Receptor 1) interact closely with Otoraplin indicating a potential collaborative role in signal cascade events which lead to desired cellular outcomes.

Research so far associates Otoraplin with otosclerosis a condition affecting bone growth in the ear and hearing loss. Abnormal regulation or expression of Otoraplin might disrupt normal ear tissue processes potentially causing these conditions. The involvement of FGFR1 in similar disorders further suggests that Otoraplin might play a relevant role in the pathological development associated with these auditory impairments.