Recombinant Human OTUB2 protein
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Recombinant Human OTUB2 protein is a Human Full Length protein, in the 1 to 234 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
C14orf137, OTB2, OTU2, OTUB2, Ubiquitin thioesterase OTUB2, Deubiquitinating enzyme OTUB2, OTU domain-containing ubiquitin aldehyde-binding protein 2, Otubain-2, Ubiquitin-specific-processing protease OTUB2
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human OTUB2 protein (AB106896)
3ug by SDS-PAGE under reducing conditions and visualized by coomassie blue stain.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
This protein influences cellular processes by interacting with ubiquitin-conjugating enzymes. OTUB2 often joins complexes that include ubiquitin-proteasome machinery components. Through these interactions it controls protein stability and degradation impacting cell cycle progression and DNA damage response. OTUB2's activity is essential for maintaining protein homeostasis which affects how cells respond to stress and changes in their environment.
Pathways
OTUB2 plays roles in the ubiquitin-proteasome and DNA repair pathways. In these pathways its interaction with other proteins like UBC13 and RAD51 is important for its function. These interactions help repair DNA damage and modulate the immune response. By regulating the stability of key signaling proteins OTUB2 ensures proper pathway function and cellular homeostasis.
Specifications
Form
Liquid
Additional notes
ab106896 is purified using conventional chromatography techniques.
General info
Function
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.
Sequence similarities
Belongs to the peptidase C65 family.
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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