Recombinant Human OXLD1 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OXLD1 also known as oxidoreductase-like domain 1 acts as an oxidoreductase enzyme that plays a role in catalyzing electron transfer reactions. The protein has a molecular mass of approximately 35 kDa and is expressed in various tissues but shows higher levels in liver and kidney cells. The structure of OXLD1 facilitates its involvement in redox reactions impacting several biochemical processes within these tissues.

Biological function summary

The enzymatic activity of OXLD1 influences cellular redox homeostasis impacting cellular metabolism and signaling. OXLD1 actively participates in a protein complex that modulates redox-sensitive transcription factors affecting gene expression linked to oxidative stress responses. This function highlights its role in maintaining cellular balance and adapting cellular activities in response to stress factors.

Pathways

The activities of OXLD1 integrate into the oxidative phosphorylation and glycolysis pathways influencing energy production and metabolism. In oxidative phosphorylation OXLD1 interacts with the NADH dehydrogenase complex which plays a significant part in the electron transport chain. Through these interactions OXLD1 establishes a regulatory connection with other proteins like NADH dehydrogenase contributing to ATP production and metabolic regulation.

OXLD1 shows relevance to conditions involving oxidative stress and metabolic imbalance such as diabetes and atherosclerosis. Research indicates interaction of OXLD1 with superoxide dismutase a protein involved in detoxifying reactive oxygen species. These interactions suggest a potential role in influencing the development and progression of these disorders. Understanding how OXLD1 functions in these contexts may aid in developing therapeutic strategies targeting oxidative stress-related pathologies.